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Title : A Case Report of Atherosclerosis Disease with Clinical Polymorphism

Article Date Accepted: !dateAccepted; | Article Date Published : 4 May 2018 | Page No.: 3771-3773

Abstract

We report the case of  a 56 year-old female patient with multiple cardiac risk factors. At the first medical evaluation the patient presented suggestive symptoms for aortic dissection associated with claudication pain in the lower limbs. Physical examination revealed significant blood pressure asymmetry, systolic heart murmur on the left carotid and subclavian artery, as well as absent pulse in the left radial artery and bilateral femoral arteries. The first electrocardiogram and echocardiography revealed normal values and biologically a moderately high level of blood glucose and lipid profile. The thoraco-abdominal computed tomography angiography infirmed the first diagnostic hypothesis and revealed a quasi-complete left subclavian artery thrombosis, quasi-complete infrarenal abdominal aorta thrombosis extended to the common iliac arteries and also the tight inferior mesenteric artery stenois. Doppler ultrasound of carotid artery and lower limb arterial spindles revealed diffuse atherosclerotic lesion with high significance in the left subclavian artery with the occurrence of the subclavian theft syndrom. The surgical resolution of the main lesion was required so the patient was redirected to the Cardiovascular Surgery Clinic where the aortobifemural bypass was performed using a  Dacron prosthetic graft. The presence of multivascular atherosclerotic disease in a female patient with atypical symptoms and fortuitous diagnosis of the main lesion indicated the need for urgent surgical treatment.

Introduction

As a general definition atherosclerosis is a chronic inflammatory process that affects multiple vascular territories and is characterized by thickening of the intima and the middle layer of arteries with loss of vascular wall elasticity.

The main lesion is the atheroma plaque, consisting mainly of lipids, fibrous tissue and inflammatory cells. This lesion passes through different stages of development.

Complications of atherosclerosis result from fissure, erosion or rupture of the plaque and thrombus formation on its surface, which facilitates plaque growth and the onset of ischemia and necrosis. This event is the cause of clinical manifestations and explains the use of the term atherotrombotic disease.

Atherosclerosis represents a systemic pathology that affects arteries at different sites simultaneously with dissimilar degrees of progression and tend to develop in coronary arteries, carotid, vertebral and cerebral arteries, as well as in lower limb arteries (iliac, femoral arteries).

Leriche syndrome is s clinical triad that associates claudication, functional impotence and absent or decreased femoral pulses, an expression of aortoiliac occlusion.

Material and method

A 56 year-old female patient with multiple cardiac risk factors showed up at the cardiology department following high

intensity anterior thoracic pain with posterior radiation, accompanied by dyspnea on moderate exertion and vertigo, and intermittent claudication after less than 200 meters of walking.

Physical examination revealed significant asymmetry on arterial blood pressure measurement (right arm = 120/60 mmHg, left arm = 80 / 60mmHg), systolic murmur on the left carotid artery and left subclavian artery, as well as absence of left radial pulse and femoral pulses bilaterally.

Admission electrocardiogram revealed: regular sinus rhythm with 70 beats per minute; QRS axis +60 degrees, normal morphology.

Echocardiography examination revealed normal cardiac chamber sizes, concentric hypertrophy of left ventricle with diastolic dysfunction, posterior mitral ring calcification, aortic atheromatosis, normal contractility of left ventricle walls; ejection fraction 60%, without pericardial fluid, without intracavitary formations.

Biological examination: moderately elevated blood glucose (fasting glucose level between 136 and 163 mg%, glycosylated hemoglobin 6.3%) and lipid profile (total cholesterol 214 mg / dl, LDL cholesterol 144 mg / dl, triglyceride 198 mg / dl).

These findings raised the suspicion of a thoracoabdominal dissection, but the thoracoabdominal computed tomography angiography infirmed the first diagnostic hypothesis and revealed the quasi-complete left subclavian artery thrombosis( fig.1) with a length of 26 mm, at 12 mm from the origin, with distal reperfusion; a quasi-complete infrarenal abdominal aorta thrombosis on the last 30 mm (fig.2), extended to the common iliac arteries(fig.3) 18 mm from the origin on the right side and 15 mm from the origin on the left side, with permeable internal and external iliac arteries; tight stenosis of the inferior mesenteric artery at the origin on a length of 5 mm.

Figure 1 Left subclavian artery thrombosis

Figure 2 Pre-bifurcation abdominal aortic thrombosis

Figure 3 Common iliac artery thrombosis

The diffuse plurivascular lesions revealed by the computed tomography exam (CT) led to further investigations of the vascular affection that brought additional data. Thus, the Doppler ultrasound of carotid artery showed an intima-media thickness objectifies a 0,8 mm; calcified, irregular plaques at the right common carotid artery bifurcation and at the origin of right internal carotid artery with a 30% stenosis; calcified plaques at the left common carotid artery bifurcation and at the origin of the left internal carotid artery with a 40-50% stenosis; calcified plaques at the origin of the right subclavian artery with a 40% stenosis; a 90-95% stenosis at the origin of left subclavian artery with appearance of subclavian steal syndrome.

The arterial Doppler ultrasound of lower limbs revealed systolo-diastolic flow in the common femoral arteries; fibrous plaques of the left femoral and right popliteal arteries, with systolo-diastolic flow, slightly inhomogeneous fibrous plaques in the right and left, anterior and posterior tibial arteries with 40-50% stenosis and monophasic flow up to the distal third terminal aortic thrombosis with refilling in the external iliac arteries showing systolic-diastolic flow.

Clinical improvement was not achieved during hospital stay under treatment with low molecular weight heparin (LMWH), peripheral vasodilators and statins, so the patient was referred to the Cardiovascular Surgery Clinic where the aortobifemural bypass was performed using a Dacron prosthetic graft (fig.4,5). Intraoperative, it was noticed a compensatory development of multiple, large collateral arteries and veins that raised the surgical risk, but the intervention was realised without major incidents with favorable postoperative outcome.

Figure 4 Intraoperative aspect-bifurcation of the abdominal aorta

Figure 5 Intraoperative aspect - Dacron prosthetic graft

The patient's evolution one year after surgery was favorable with the resumption of moderate cotidian activity and compliance with diet.

DISCUSSION

Leriche syndrome was first described by Quain in 1847 and later on by Leriche and Morel in 1940. [ 15 ] Leriche syndrome represents a category of atherosclerotic occlusive disease.

Incidence and aetiology are unknown, but other described aetiologies are exposure to radiation, luetic aortitis, congenital rubella infection, thrombangitis obliterans Winiwarter–Buerger and Takayasu arteritis.

Symptoms occur often in the 4th–5th decade of life [ 16 ] and are represented by intermittent claudication and arterial insufficiency of the extremities like muscle atrophy, pain, myalgias, trophic troubles paleness, neurologic symptoms, oedema, fatigability, an aggravation of hypertension or newly recognised hypertension, weight loss and erectile dysfunction [ 15 , 17 ]. Typical risk factors of Leriche syndrome are hypertension, diabetes mellitus, smoking and hyperlipaemia.[ 17 ].

Physical examination typically shows differences between blood pressure of arms and legs. Femoral and calf arteries are decreased and the ankle–brachial indexes are reduced on both sides [ 17 , 18 ]. Diagnosys of Leriche syndrome is made by Computed Tomography scan(CT) or Magnetic Resonance Imaging exams(MRI).

Standard therapy is represented by surgical revascularisation [ 17 ]. Surgical standard management alternatives are bypass grafts and endarterectomy [ 18 ]. Aortofemoral bypass is the most common grafting technique.

CONCLUSIONS

The primary illness in this case, Leriche syndrome is commonly diagnosed in patients with atherosclerotic involvement affecting multiple vascular territories. The development of occlusive lesions is a complex, long process and symptoms could be masked by the clinical expression of comorbidities until advanced stages. A late diagnosis in these cases significantly increases morbidity-mortality.

Treatment of Leriche syndrome is surgical and consists of aortoiliac endarterectomy and aortobifemoral bypass. Alternative procedures include percutaneous stent-supported angioplasty and axillofemoral bypass.

The case is meant to highlight the discrepancy between the diagnostic hypotheses raised by patient's polymorphism clinical picture and the severe arterial lesion, as assessed by the imaging examinations performed.

References

  1. Leriche Syndrome Presenting with Multisystem Vaso-Occlusive Catastrophe McCoy Eric, Patierno Shaheena, Lotfipour Shahram. Western Journal of Emergency Medicine.2015-jul;:583-586. CrossRef Google Scholar
  2. Huge anastomotic femoral pseudoaneurysm following aorto-bifemoral bypass Wu AY.-W., Al-Jundi W, Ziadi Z, Barkat M, Khushal A. Case Reports.2011-apr. CrossRef Google Scholar
  3. Angiographic documentation of aortoiliac occlusion in Leriche\textquotesingles syndrome Takigawa Masateru, Akutsu Koichi, Kasai Satoshi, Tamori Yuiichi, Yoshimuta Tsuyoshi, Higashi Masahiro, Takeshita Satoshi. Canadian Journal of Cardiology.2008-jul. CrossRef Google Scholar
  4. Leriche Syndrome Detected by 64-MDCT Norimatsu Kenji, Shiga Yuhei, Miura Shin-ichiro, Saku Keijiro. Internal Medicine.2011;:1263-1263. CrossRef Google Scholar
  5. Atherosclerotic Cardiovascular Disease Beginning in Childhood Hong YoungMi. Korean Circulation Journal.2010. CrossRef Google Scholar
  6. Association Between Ventilatory Pulmonary Function and Metabolic Syndrome Components in Predicting the Cardiovascular Risk in Symptomatic Smokers Puiu Ligia, Nemes Roxana, Petrovan Ancuta, Ulmeanu Ruxandra, Mihaltan Florin, Deleanu OanaClaudia. Chest.2016-oct. CrossRef Google Scholar
  7. Screening Asymptomatic Subjects for Subclinical Atherosclerosis Shah PredimanK. Journal of the American College of Cardiology.2010-jul;:98-105. CrossRef Google Scholar
  8. Excess body mass index- and waist circumference-years and incident cardiovascular disease: The CARDIA study Reis JaredP, Allen Norrina, Gunderson EricaP, Lee JoyceM, Lewis CoraE, Loria CatherineM, Powell-Wiley TiffanyM, Rana JamalS, Sidney Stephen, Wei Gina, Yano Yuichiro, Liu Kiang. Obesity.2015-mar;:879-885. CrossRef Google Scholar
  9. Cardiovascular Risk Factors and Atherosclerosis in Young Women: Atherosclerosis Risk Factors in Female Youngsters (ARFY Study) Knoflach M, Kiechl S, Penz D, Zangerle A, Schmidauer C, Rossmann A, Shingh M, Spallek R, Griesmacher A, Bernhard D, Robatscher P, Buchberger W, Draxl W, Willeit J, Wick G. Stroke.2009-feb;:1063-1069. CrossRef Google Scholar
  10. Increased arterial stiffness in children with Williams syndrome and normal blood pressure Bassareo PierPaolo, Mercuro Giuseppe. Blood Pressure Monitoring.2010-oct;:257-261. CrossRef Google Scholar
  11. Secondhand smoke exposure is associated with increased carotid artery intima-media thickness: The Bogalusa Heart Study Chen Wei, Yun Miaoying, Fernandez Camilo, Li Shengxu, Sun Dianjianyi, Lai Chin-Chih, Hua Yingxiao, Wang Fu, Zhang Tao, Srinivasan SathanurR, Johnson CarolynC, Berenson GeraldS. Atherosclerosis.2015-jun;:374-379. CrossRef Google Scholar
  12. MRI of atherosclerosis: diagnosis and monitoring therapy Kramer ChristopherM, Anderson JustinD. Expert Review of Cardiovascular Therapy.2007-jan;:69-80. CrossRef Google Scholar
  13. Noninvasive assessment of preclinical atherosclerosis Lane HelenA, Smith JamieC, Davies JStephen. Vascular Health and Risk Management.2006-jan;:19-30. CrossRef Google Scholar
  14. Socioeconomic Status in Association with Metabolic Syndrome and Coronary Heart Disease Risk Kim JiYoung, Kim SungHi, Cho YoonJeong. Korean Journal of Family Medicine.2013. CrossRef Google Scholar
  15. THE SYNDROME OF THROMBOTIC OBLITERATION OF THE AORTIC BIFURCATION LERICHE RENÉ, MOREL ANDRÉ. Annals of Surgery.1948-feb;:193-206. CrossRef Google Scholar
  16. Patient with Acute Myocardial Infarction and Leriche Syndrome Brajkovic AnaVujaklija, Gornik Ivan, Zlopaša Ozrenka, Vrdoljak NinaGubarev, Radonic Radovan, Gašparovic Vladimir. Internal Medicine.2010;:349-350. CrossRef Google Scholar
  17. Leriche Syndrome Frederick Michael, Newman John, Kohlwes Jeffrey. Journal of General Internal Medicine.2010-jun;:1102-1104. CrossRef Google Scholar
  18. Leriche syndrome Lee Wei-Jing, Cheng Yung-Ze, Lin Hung-Jung. International Journal of Emergency Medicine.2008-aug;:223-223. CrossRef Google Scholar

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Article Details

Issue: Vol 5 No 5 (2018)
Page No.: 3771-3773
Section: Articles
DOI: https://doi.org/10.18535/ijmsci/v5i5.02


 How to Cite
Botez, A., Clim, A., Spiridon, M., Petraș, S., & Petriș, A. O. (2018). A Case Report of Atherosclerosis Disease with Clinical Polymorphism. International Journal of Medical Science and Clinical invention, 5(5), 3771-3773. https://doi.org/10.18535/ijmsci/v5i5.02

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