Abstract

Purpose: - To analyze the level of serum Carcinoembryonic antigen (CEA) before and after Different Cycle Of chemotherapy in oesophagus cancer patients. Methods: - For the study total 120 cases of carcinoma of esophagus of stage I, stage II stage III and Stage IV (before and after different cycle of chemotherapy) were selected. All patients were clinically and histological diagnosed. 42 age and sex matched healthy normal subjects selected as control. CEA activity was measured in the in the serum of control group (n=42) and in patients with esophagus cancer (n=120). Results: - Mean CEA activity in serum was significantly higher in oesophagus cancer patients as compared to control (p

<0.001). After chemotherapy (stage II) the activity of CEA was significantly higher than before chemotherapy (stage I). In stage II (after first cycle of chemotherapy) activity was significantly decreased than stage III (before chemotherapy) and the activity of CEA was significantly decreased in stage IV (after third cycle of chemotherapy) than stage III (after second cycle of chemotherapy). Conclusion:- Based on the data from our study, it can be stated that serum CEA measurement in plasma may be useful tumor marker in esophageal cancer, its activity might helpful to predict the response of chemotherapy in advance stage of cancer. An initial increased level of CEA before and first cycle of chemotherapy may not indicate tumor progression, but may be represent a transient tumor marker surge phenomenon after second and third cycle of chemotherapy in patients responding to treatment.. Statistically significant change in tumor marker CEA level during the process of treatment in esophageal cancer patients, with a positive response and no established disease progression during study period, near about 12 months after the treatment, point to CEA as an important predictive factor.>

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