Objective: To study oral glucose tolerance test in offspring of uniparental and biparental diabetics in a tertiary care hospital in north India. Methods: This was a prospective comparative observational study. A total of 14 families were studied (7 uiniparentaleither husband or wife diabetic, 7 biparental-both husband and wife were diabetic).their all offspring were recruited who consented for the study. Each offspring was subjected to a detailed history with clinical examination. Anthropometric parameters, glucose levels, lipid profile, serum uric acid and microalbuminuria were measured. Results: More than one third of patients of Uniparental (46.7%) and 13.3% of Biparental were between 26-30 years of age. Most of the patients in both the groups were males.There was no significant (p>0.05) difference in fasting 1 hour and 2 hour plasma glucose, anthropometric parameters, lipid profile, serum uric acid and microalbuminuria between offspring of Uniparental and Biparental Diabetics. However, increased level of plasma glucose, lipid profile, serum uric acid and microalbuminuria was observed in Uniparental and Biparental than controls. Conclusion: The findings of this study reflect that there is high level of plasma glucose , lipid profile and serum uric acid among the offspring of diabetics, probably due to some genetic predisposition. If parents with diabetes become more conscious about their status and lead life more carefully, the rate of diabetic offspring will be lower.