A Rare Case of Mild Spontaneous Pneumomediastinum Associated with Asthma Exacerbation.

Introduction:
The presence of free air within the mediastinum, that is not associated with trauma, is known as spontaneous pneumomediastinum [1].
The disease was originally described by Rene Laennec in 1819. The word spontaneous was introduced by Hamman later in 1939.The condition can result from an injury that leads to air leakage into the mediastinum from the lung . Spontaneous indicates that it is encountered in patients with underlying lung diseases or without any medically relevant conditions as compared to that secondary pneumothorax that results from trauma [2]. The pathophysiological mechanisms underlying pneumomediastinum are six:
1) Direct mechanism
2) Hamman-Macklin mechanism
3) Subfascial route (secondary to pneumothorax or chest wall injury)
4) Subserosal route:


Introduction:
The presence of free air within the mediastinum, that is not associated with trauma, is known as spontaneous pneumomediastinum [1].The disease was originally described by Rene Laennec in 1819.The word spontaneous was introduced by Hamman later in 1939.The condition can result from an injury that leads to air leakage into the mediastinum from the lung .Spontaneous indicates that it is encountered in patients with underlying lung diseases or without any medically relevant conditions as compared to that secondary pneumothorax that results from trauma [2].The pathophysiological mechanisms underlying pneumomediastinum are six: 1) Direct mechanism 2) Hamman-Macklin mechanism 3) Subfascial route (secondary to pneumothorax or chest wall injury) 4) Subserosal route: -Descending: via middle cervical aponeurosis.
-Ascending: via retroperitoneal diaphragmatic orifices.5) By the pleuro-mediastinal route 6)Secondary to infection by aerogenic germs.In particular, according to Hammann's pathogenetic hypothesis, later confirmed by Macklin, the event would occur following a spontaneous pneumothorax.There is a rupture of the 'pulmonary marginal alveoli', placed in contact with the pulmonary vessels, interstitial tissue, bronchi and bronchioles, which are subjected to increased pressure stress during the event.The rupture would be due to an altered pressure gradient between the alveolus and the blood vessel or due to a sudden increase in intra-alveolar pressure (asthma crisis), Valsalva manoeuvre, vomiting, persistent coughing, deep breathing, intense exercise, Heimlich manoeuvre, abrupt reduction in pulmonary arterial flow (pulmonary embolism or altered venous return to the heart).
Once the alveolus has ruptured, the air penetrates the interstitium resulting in 'interstitial emphysema' and through an 'escape route' along the perivascular sheaths at first the air reaches the pulmonary hilum by an anterograde route, from there the air distributes either upwards or downwards, in some cases dislodging the diaphragmatic parietal pleura, in other cases passing through the mediastinal parietal pleura (pathophysiological mechanism not unanimous in the literature).A very rare eventuality described in the classification and for which it is often difficult to find a cause since the pneumomediastinal event is acute, is represented by infection with airborne germs (Klebsiella, Enterobacteriaceae, clostridia, etc.) especially in the post-cardiothoracic surgery [3].In the differential diagnosis of Pneumomediastinum causes, there is also asthma exacerbation.We hope that this case will be helpful to increase awareness among readers, and could help to identify spontaneous pneumomediastinum early in recent asthma exacerbation, as well as highlighting how such International Journal of Medical Science and Clinical Invention, vol. 10, Issue 05, May 2023 cases can be managed successfully with conservative measures in ambulatory setting.

Case Presentation:
In January 2023, a 20-year-old Caucasian male came to my attention with worsening dyspnea.In the collection of anamnestic data: farm laborer, reported that in the past he had recently engaged in unprotected sexual intercourse, no use of drugs reported, no drug allergy, negative prick test performed in the past, kept farm animals (chickens and hens) .Familiarity with bronchial asthma (mother) smoker of a pack of fifteen cigarettes a day, psoriasis.He reported recent episodes (December 2022) of yellowish catarrhal cough with a previous episode of cough associated with stinging chest pain, which then disappeared spontaneously.At the outpatient visit, the patient reported only dyspnoea and an unproductive cough; he was asymptomatic due to pneumomediastinum.On physical examination of the chest there was no evidence of subcutaneous emphysema, blood pressure: 120/80mmHg, heart rate: 68 beats/minute, peripheral oxygen saturation: 98% in ambient air, diffusely harsh and soft vesicular murmur with many rhonchi in forced expiration.It can be seen that after the administration of 400mcg of salbutamol there is a partially positive response to the bronchodilator (+10% FEV1 and +35% parameter FEF25-75 which is the expression of FVC in the small airways).Therefore I started treating the patient with a combination therapy of inhaled corticosteroids and long acting beta two agonists twice a day for 3 months combining for the first month macrolide only for six days and then doxycycline forty milligrams a day .Finally, I advised the patient to give up smoking completely.Furthermore, I advised to perform the CT scan at three months and subsequent blood tests; as you can see in

G-H-I-L-M-N:
Chest CT scan carried out at three months on April 2023, in the course of regular intake of inhaled corticosteroid and long-acting bronchodilator (pre-Metred Dose Inhaler with extrafine formulation) plus macrolides and doxiciclin, showing complete resorption of the apical pneumomediastinum and complete regression of the previously reported bronchiolitic areas with disappearance of the right basal nodule.

Discussion:
For the vast majority of patients in hospital setting with these condition, the treatment is conservative, which includes bed rest, oxygen therapy, and adequate analgesia [2].Asthma is the most common chronic respiratory disease worldwide and its prevalence is increasing.Acute asthma complications are often the reason for admission to emergency healthcare service.Nevertheless, there are also rare complications of asthma such as spontaneous pneumomediastinum, which is often difficult to diagnose

Conclusions:
The acute event can degenerate into pneumothorax which in some cases may require chest surgery.In the clinical case described, the prognosis was excellent as the pathology regressed spontaneously even following pharmacological therapy.It is evident from the clinical experience described and from the existing literature on the subject, that there is an association between the development of the acute event of spontaneous pneumomediastinum, bronchitic exacerbation associated with infectious bronchiolitis caused by an atypical microorganism (Chlamydia pneumoniae) and the diagnosis of Bronchial asthma always needs to be investigated, starting from the collection of the patient's clinical data, which can sometimes bring out interesting data on lifestyle habits and possible exposure to risk factors, potential causes of the clinical and symptomatological picture.The case is interesting to publish since rare cases of spontaneous pneumomediastinum associated with bronchial asthma emerge from the literature and spontaneously regress.The role of the pulmonologist in the management of these cases remains crucial to modify the natural clinical International Journal of Medical Science and Clinical Invention, vol. 10, Issue 05, May 2023 history of the disease.Cigarette smoking cessation and protected sexual relations represent a goal to be achieved in younger patients by sensitizing them through educational campaigns.

Table 1 :
Spirometry tests at time zero with broncho-reversibility test and at three months with inhaled corticosteroids and beta two agonist long acting twice day; with stability of the spirometric values compared to the volumes described during the broncho-reversibility test .

Table 2 and Image 1.
an increase in eosinophilic cells in the leukocyte count(370 cells) the latter data correlates with bronchial asthma with an eosinophilic component.International Journal of Medical Science and Clinical Invention, vol. 10, Issue 05,

May 2023 Tab. 2 Blood Test at three months Results Chlamydophila Pneumoniae IgM 1,3 AU (positive) Chlamydophila Pneumoniae IgG <10 AU/ml (negative) Chlamydophila Pneumoniae IgA <10 AU/ml (negative) Mycoplasma Pneumoniae IgA <10 index (negative) Mycoplasma Pneumoniae IgM 0,4 index (negative) Mycoplasma Pneumoniae IgG Twenty-two index (positive) ESR
Time zero chest CT scan showing areas of air bubbles within the superior mediastinal space C: Time zero chest CT scan showing areas of bronchiolitis due to lower respiratory tract infection prevalent in the middle lobe associated with bilateral bronchial ectasia Chest CT scan at time zero showing areas of bronchiolitis due to lower respiratory tract infection prevalent in lower lobes with bilateral bronchial ectasia and in the peripheral subpleural area of the right lower lobe, a subsolid nodule of about five millimiter of diameter.