@article{ÇELİK_2018, title={Clınıcopathologıcal Features of Melanoma In Muğla}, volume={5}, url={https://valleyinternational.net/index.php/ijmsci/article/view/1416}, DOI={10.18535/ijmsci/v5i8.01}, abstractNote={<p><strong>Introduction:</strong> Melanoma<strong><em>, </em></strong>a neoplasm of melanocytes is  the most aggressive and life-threatening skin cancer. The incidence of it is higher in fair skinned people as the Ultraviolet-light exposure is the most important risk factor with the malignant transformation of the nevi. So here we aimed to determine the clinical and histopathological findings of our Melanoma cases.</p> <p><strong>Method: </strong>We reviewed the tumors of the patients who received the diagnosis of Melanoma at our Pathology Laboratory, between 2011 and 2018 retrospectively.</p> <p><strong>Results and Discussion: </strong>There were 43 skin Melanoma cases. 21(48.8%) of the patients were female, 22(51.2%) were male.  The median-age in females was 68, while 64 in males. 35(81.4%) of the 43 cases were Nodular Melanoma(NM), 3(7%) were Superficial-spreading melanoma(SSM) and 5(11.6%) were Melanoma-in-situ(MIS). None of the SSMs and MISs had metastasis to anywhere.</p> <p>7(20%) of the NMs had lymph-node and 3(8.6%) had soft tissue metastasis at the time of diagnosis. 4 developed lung, brain, stomach and nasopharinx metastases in the following 2 years. The ratio of the Clark Level 2,3,4,5 of NMs were 11.4%, 28.6%, 45.7% and 14.3% respectively. Most of the metastatic cases were Clark Level 3 or 4. This study showed that Melanoma is generally diagnosed at WHO-Stage 2 or 3 and this cause worse prognosis as the cure rates depend greatly on the stage.</p> <p><strong>Conclusion:</strong> As a result it’s very important to self-examine the existing nevi on our skin in order to detect the early malignant transformation to Melanoma and protect our skin from Ultraviolet-light.</p>}, number={8}, journal={International Journal of Medical Science and Clinical Invention}, author={ÇELİK, Özgür İLHAN}, year={2018}, month={Aug.}, pages={3970–3973} }