TY - JOUR AU - Kumar Soni, Dr. Kishore AU - Singh, Dr. Sushil PY - 2019/02/28 Y2 - 2024/03/28 TI - Genes Expression in Type 1 Diabetes: An Update JF - International Journal of Medical Science and Clinical Invention JA - ijmsci VL - 6 IS - 2 SE - Articles DO - 10.18535/ijmsci/v6i2.09 UR - https://valleyinternational.net/index.php/ijmsci/article/view/1924 SP - 4327-4331 AB - <p>Type 1 Diabetes (T1D) is autoimmune disease with a sturdy genetic component, which, through interactions with particular environmental factors, causes disease onset. T1D usually reveals in early to mid-childhood through the autoimmune destruction of pancreatic cells resulting in a lack of insulin production. Traditionally, prior to genome-wide association studies (GWAS), six loci in the genome were fully established to be associated with T1D. The originations of genetic factors involved in T1D through GWAS present the first step in a long process leading to cure. Genes uncovered using this approach is indeed necessary to disease biology and will define the key molecular pathways leading to cure of T1D. However, such genome wide scans can lack coverage in certain regions where it is difficult to , thus, it is possible that other loci with practical effect sizes remain to be uncovered through whole genome sequencing approaches. In this review, we address recent expansions in the genetics of T1D and provide an update on the latest predisposition loci added to the list of genes involved in the of T1D</p> ER -