International Journal of Medical Science and Clinical invention 2018-10-22T13:55:33+00:00 Valley International Open Journal Systems <p style="text-align: justify;"><strong>International Journal of Medical Science and Clinical&nbsp;invention </strong></p> <p style="text-align: justify;">IJMSCI is an international, peer-reviewed open access journal of medicine published in English. The journal's publisher is the Valley International</p> <p style="text-align: justify;">The Journal aims at publishing evidence-based, scientifically written articles from different disciplines of medical sciences. The Journal welcomes articles of general interest to audiences of medical researchers especially when they contain new information. Articles of clinical evaluation of drugs and other therapies,&nbsp;epidemiology&nbsp;studies in general population, studies on pathogenic organisms and toxic materials, toxicities and adverse effects of therapeutics are welcome.</p> <p style="text-align: justify;">When written in language other than English and has not been propagated in any international information services (abstract journals), secondary publication of the article is negotiable.</p> Breast Carcinoma with Choriocarcinomatous Features 2018-10-22T13:55:33+00:00 Dr. Amrisha Jaiswal Dr. Parul Gupta Dr. Nirupma Lal Dr. Nida Parveen <p>Breast cancer with choriocarcinomatous&nbsp; features is a rare variant of breast malignancy with poor prognosis and poor response to treatment. The tumour cells express high expression of human chorionic gonadotropin in cancer cells such as multinucleated syncytioblast like giant cells. The histogenetic origin of these cells is unknown but the most reliable theory involves a metaplastic process. The frequently found metaplastic changes are squamous, spindle cells, or osseous,&nbsp; chon­droid, or matrix production. &nbsp;Non-gestational choriocarcinomatous differentiation is extremely rare in breast neoplasms. Choriocarcinomatous differentiation has also been described in tumour arising from many organs including lung, rectum, colon, stoamach and urinary bladder. Most of the patient with choriocarcinomatous features presents&nbsp; with high grade disease, that is exhibiting an aggressive clinical course with an overall survival of less than a year. In this case report, the history, physical examination, laboratory findings and pathological findings of breast carcinoma in a 40year old woman are described. The patient underwent lumpectomy of left breast. Microscopically the tumour was reported as Invasive ductal carcinoma with choriocarcinomatous features. Nottingham grade III, ER- Negative, PR- Negative, HER2-neu Negative . Histology of choriocarcinoma in breast is distinctly unusual. Before making a confirmatory diagnosis of breast cancer with choriocarcinomatous features a possibility of metastatic choriocarcinoma to the breast should always be ruled out because of its poor prognosis.</p> 2018-10-03T01:25:58+00:00 ##submission.copyrightStatement## Speciation Speciation and Antibiogram of Staphylococcal Isolates from a Tertiary Care Hospital of North East India 2018-10-22T13:55:32+00:00 Lalhmin gmawii Lalremp uii Gracy Laldinmawii Jacinta Lalremruati A Lalzirtitri Yogesh Malvi <p><strong>Background:</strong> Infections by <em>staphylococci</em> has been one of the most common isolates among the gram positive cocci.&nbsp; However emergence of methicillin resistant strains have led to failure of many antibiotics. The present study was undertaken to find out the species of staphylococcal isolates prevalent in Civil Hospital Aizawl, and to correlate its antibiotic sensitivity pattern due to the fact that they are the leading cause of infections and bacteremia.</p> <p><strong>Methods:</strong> Specimens collected between January 2017 to December 2017 were processed using standard conventional methods. Staphylococcal isolates were speciated and antibiogram done using automated culture methods. Interpretation were done as per CLSI guidelines.</p> <p><strong>Results:</strong> 220&nbsp; non repeated clinical isolates were identified as <em>Staphylococcus</em> species of which 45.4% were <em>S aureus</em> and 54.6%were CoNS. Out of 120 CoNS,&nbsp; 36.6% were <em>S&nbsp; haemolyticus,</em> 26.7% were <em>S&nbsp;&nbsp; epidermidis</em>,&nbsp; 12.5% were <em>S saprophyticus</em>, 12.5% were <em>S hominis</em>,&nbsp; 3.3% were <em>S xylosus</em>,3.3% were <em>S cohinii</em>,&nbsp; 1.7% were <em>S lentus</em>,&nbsp; 1.7%&nbsp; were<em> S warneri</em>, 1.7% were <em>S lugdunensis</em>, and 9.2% were unidentified CoNS. Among the <em>S aureus</em> , 52% were MRSA and among&nbsp; CoNS , 55% were MRCoNS. All of the isolates were sensitive to Vancomycin.</p> 2018-10-03T01:59:21+00:00 ##submission.copyrightStatement## Prevalence of Deep Venous Thrombosis (DVT) in Jeddah 2018-10-10T01:54:13+00:00 Awad Elkhadir Mohammad Wazzan Ahmed Abduljabbar Nawaf Meshal Badwi Faisal Mohammed Hendi Khaled Mohammed Al-Shomrani Abdullmola Atwan Al-Malawi <p><strong>Objective:</strong> To study the prevalence of deep vein thrombosis (DVT) of all adult patients scanned by Doppler ultrasound in the Department of Vascular Imaging (DVI) at&nbsp; King Abdulaziz University Hospital (KAUH) in Jeddah for patients who suspected to have DVT over a period of three years.</p> <p><strong>Methods:</strong> Retrospective study which included all the suspected cases of DVT visited &nbsp;KAUH during the period between January 2013 to December 2015.</p> <p><strong>Results:</strong> 1201 patients of patients were diagnosed to have DVT with mean age of54.8±19.8 years. There were 708 females and 493males. Doppler ultrasound detected 186 (15.7%) DVT. 76.2% was found symptomatic such as pain, swelling and edema. Elderly has been found to be the most common risk factor 425 (27.09%).</p> <p><strong>Conclusion:</strong> A high incidence of DVT in Jeddah 15.7 % and females were affected more than males.</p> 2018-10-10T01:54:13+00:00 ##submission.copyrightStatement## The Effect of Coffee And Tea On Immersion of Thermoplastic Acetal Resin and Polyamide 12 2018-10-12T08:38:17+00:00 Silvani Sona Taufik Sumarsongko Erna Kurnikasari Lisda Damayanti <p>Tooth loss causes unstable occlusion which affects person’s mastication, phonetic and esthetic. Removable partial denture is a suitable treatment to overcome these conditions. However, patients sometimes refuse to receive the treatment due to several problems such as economic problem, anxious with poor prosthetic’s retention and aesthetic dissatisfaction resulting from the use of metal claps. There are two types of thermoplastic resin material which used as aesthetic crystal material alternative, namely polyoxymethylene (acetal resin) and polyamide 12 (thermosens).</p> <p>This study aimed to determine the highest colour change between acetal resins and thermosens, knowing the type of solution that causes the highest colour change in acetal resin and thermosens and to ascertain time required for the colour change of acetal resins and thermosens.</p> <p>A laboratory experimental study was performed by using 48 samples consist of 24 acetal resin plates and 24 thermosens plates, which each divided into four groups soaked in coffee and tea for 7 days and 14 days. The result of statistical test of Mann Whitney in the study group obtained information of p value on variable National Bureau of Standards smaller than 0.05 (p value &lt;0.05) which considered as significant or statistically significant. The conclusion of this study showed acetal resin experienced a higher color changes. Tea solution is the highest solution causing discoloration. Acetal resins and thermosens change colour after use for 2.7 years.</p> <p>The conclusion of this study showed that acetal resin undergoes a higher color change compared with thermosens. Tea solution is the highest solution causing discoloration. Acetal resins and thermosens change color after immersion&nbsp; for 7 days.</p> 2018-10-12T08:38:17+00:00 ##submission.copyrightStatement## A Rare Primary Skeletal Lymphoma in the Tibia Mimicking Osteomyelitis 2018-10-17T03:02:03+00:00 Dr. Selim Yalçın Dr. Korcan E. Gültekin <p>The primary skeletal lymphoma is a rare disease that accounts for only 0.5% of all extra nodal, The pathogenesis of the lymphoma that occurs in the muscles is not clear. It has been suggested that the muscle lymphoma may originate from abnormal lymph nodes within the muscles. In this report , there is a case&nbsp; about this rare non-hodgkin lymphoma. A 42-year-old female patient presented to our clinic with complaints of pain in the left leg. In the bone biopsy from the lesion of the patient; it is seen that atypical cells with diffuse infiltration into adjacent striated muscle tissue The findings were evaluated as diffuse large B-cell lymphoma.&nbsp; Primary extra nodal lymphomas in the skeletal muscle are radiologically similar to osteomyelitis, so in the case of a patient complaining of pain and swelling in the adjacent skeletal muscle, primary extra nodal lymphoma should be considered in differential diagnosis, although it is rare</p> 2018-10-17T03:02:03+00:00 ##submission.copyrightStatement## Burden Of Mycobacterium ulcerans Disease (Buruli ulcer) In Ogbaru District, Anambra State, Nigeria 2018-10-20T01:04:44+00:00 Ndubuisi O. Nwachukwu Ignatius U. Ejiofor Elendu C. Onwuchekwa <p><strong>Background:</strong> The burden of Buruli ulcer in four communities of Ogbaru district, Anambra State, Nigeria was investigated.</p> <p><strong>Methods:</strong> Swabs were collected from the undermined edges of ulcerative lesions. Diagnosis was made by direct smear microscopy according to the WHO guidelines.</p> <p><strong>Results:</strong> Eleven new Buruli ulcer cases were identified. Age of the patients ranged from 4 to 75 years, with a mean age of 15.5 years. Overall, 81.8%of cases presented with one lesion and 18.2% cases with two lesions. The lesions occurred mostly on the leg (91%) and arm (9%). Majority of the lesions (90.9%) were ulcers and males were more infected. The main reasons for not seeking diagnosis and treatment in a hospital were that Buruli ulcer was attributed to witchcraft and the belief that treatment of Buruli ulcer in hospital was ineffective.</p> <p><strong>Conclusion:</strong> Buruli ulcer is prevalent in Ogbaru. Enhanced enlightenment of the populace will be a good measure to infection prevention and control.</p> 2018-10-20T01:04:44+00:00 ##submission.copyrightStatement## Phenotype of mitochondrial cytb mutations 2018-10-20T01:11:10+00:00 Josef Finsterer, MD, PhD Anushree Mishra, PhD <p>In a recent article, Mancuso et al. reported about a 19 years-old girl with MELAS syndrome due to the <em>cytb </em>mutation m.15092G&gt;A [1]. We have the following comments and concerns.</p> 2018-10-20T01:11:10+00:00 ##submission.copyrightStatement##