https://valleyinternational.net/index.php/ijmsci/issue/feed 2024-11-01T13:19:19+00:00 Valley International info@valleyinternational.net Open Journal Systems <p>Welcome to the International Journal of Medical Science and Clinical Invention (IJMSCI). Our journal is dedicated to publishing cutting-edge research and innovative clinical advancements in the field of medical science.</p> <p>Our mission is to serve as a platform for researchers, clinicians, and healthcare professionals to disseminate their findings and share their expertise with the global community. IJMSCI provides a wide-ranging and interdisciplinary forum for the exchange of ideas and information in the areas of medical science, clinical practice, and invention.</p> <p>We publish original research articles, review articles, case reports, and short communications in all areas of medical science and clinical invention, including but not limited to, internal medicine, surgery, pediatrics, obstetrics and gynecology, dermatology, orthopedics, neurology, and oncology.</p> <p>At IJMSCI, we strive to maintain the highest standards of quality and rigor in our publishing process. Our editorial board comprises experts from leading medical institutions worldwide, and our peer-review process ensures that only the most relevant, novel, and impactful research is published.</p> <p>We welcome submissions from researchers and clinicians around the world and encourage you to share your work with us. If you have any questions or need assistance, our editorial team is here to help.</p> <p>Join the global community of medical science and clinical invention experts and stay ahead of the curve with IJMSCI!</p> https://valleyinternational.net/index.php/ijmsci/article/view/4829 2024-10-31T09:26:18+00:00 Abdelmoumen Shad SERROUNE shad@geios.energy Dr. Khasani shad@geios.energy James Kakiecwski shad@geios.energy Marshall Brenton shad@geios.energy Abdellatif SERROUNE shad@geios.energy Deborah Basset shad@geios.energy Hicham SERROUNE shad@geios.energy Sebastien Gescot shad@geios.energy

<p>This study presents a novel approach to mitigate methane emissions while simultaneously addressing the growing demand for sustainable animal feed through the development of an engineered methanotrophic strain, Methylomicrobium buryatense 5GB1C-RO1. Utilizing advanced genetic engineering techniques, including CRISPR/Cas9 and horizontal gene transfer, we have optimized the ribulose monophosphate (RuMP) cycle and enhanced oxidase activity in this strain. The bioconversion process is facilitated by innovative bioreactor designs, including Two-Phase Partitioning Bioreactors (TPPBs) and Inverse Membrane Bioreactors (IMBRs), which significantly improve methane solubility and mass transfer. Through metabolic flux analysis and computational modeling, we have achieved high biomass yields and efficient methane utilization. The resulting biofeed demonstrates a superior nutritional profile, with optimized macronutrient content and essential components. This integrated approach not only contributes to greenhouse gas mitigation but also offers a promising solution for sustainable animal nutrition. Our findings suggest that the 5GB1C-RO1 strain and associated bioprocesses have the potential to revolutionize both environmental protection and agricultural sustainability</p>

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