International Journal of Medical Science and Clinical invention <p><strong>International Journal of Medical Science and Clinical invention</strong>&nbsp;is an international, peer-reviewed journal that welcomes original research articles and reviews on&nbsp;current advances in Medical sciences,&nbsp;preclinical&nbsp;and&nbsp;clinical medicine, and&nbsp;related disciplines.</p> <p>The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments.</p> <p><em>International Journal of Medical Science and Clinical invention&nbsp;</em>&nbsp;publishes articles which bring novel insights into&nbsp;diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on&nbsp;<strong>Clinical</strong>&nbsp;pathological sciences&nbsp;giving foundation knowledge on the overall study of human diseases. Through its publications&nbsp;<em>International Journal of Medical Science and Clinical invention</em>&nbsp;also stresses the importance of&nbsp;Medical sciences&nbsp;as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines.</p> en-US (Valley International) (Pawan lohar) Tue, 30 Apr 2019 18:27:11 +0000 OJS 60 CD30 expression and Detection of Epstein-Barr Virus-Encoded Small RNA by Real-Time RT-PCR of Classic Hodgkin Lymphoma and Their Correlation with Risk Stratification <p>More than 40% patient of Hodgkin lymphoma (HL)&nbsp;are chemoresistance and show&nbsp;<em>early disease relapse that leads to poor prognostic</em>.&nbsp;Epstein-Barr Virus (EBV) appears to have poor prognostic in HL. The CD30 expression at Hodgkin and Reed-Stenberg cells suggested has associated with advanced disease stage. The International Prognostic Score-7 (IPS) is a seven-parameter of risk stratification index for prognostic and as a consideration for&nbsp;treatment&nbsp;plan. The aim of this journal is to see&nbsp;correlation&nbsp;between EBV infection and CD30 expression with IPS-7 in Classic HL (CHL) patient.</p> <p>Case-control&nbsp;research design was done to 40 Fixed Formalin Paraffin-Embedded (FFPE) of CHL at the&nbsp;Dr&nbsp;Hasan Sadikin Hospital, Bandung. Cases were 20 patients CHL of high-risk score IPS-7 and controls were 20 patients with low-risk score. Detection of&nbsp;EBV-encoded small RNA-1 (EBER1) by Real-Time RT-PCR and Immunohistochemical staining of CD30 was performed to all samples. All data were analyzed using&nbsp;Chi-Square&nbsp;test with&nbsp;p-value&nbsp;&lt;0.05 of significant level.</p> <p>EBV was present in 10 cases of CHL (25%). The result of this study shows a different statistically significant of EBV infection (p=0.028) and CD30 expression (p=0.004) between low risk and high-risk IPS-7 HL. CD30 expression (OR= 7.429) may provide&nbsp;stronger&nbsp;factor for risk assessment for the patient with HL, compare to EBER1 detection (OR=6.000).</p> <p>This study concluded that CD30 expression and EBV Infection correlate with risk assessment IPS-7 in CHL.</p> Zahra Nurusshofa, Sri Suryanti, Afiati ., Bethy Surjawathy Hernowo Copyright (c) 2019 International Journal of Medical Science and Clinical invention Mon, 15 Apr 2019 00:00:00 +0000 The correlation of preclinical GPA score in faculty of medicine of university of baiturrahmah with national board examination result <p>Background: The National board of medical examination (“UKMPPD) has been implemented since August 2014 and has emerged a new challenge for medicine faculty in Indonesia in which there are 2769 “UKMPPD CBT” retakers in November 2017. It is the same challenge for Faculty of medicine, university of baiturrahmah (FMUNBRAH) where there are 82 CBT retakers in February 2018. The “UKMPPD” as a determinant of graduation should represent the process of conducting competency-based curriculum during preclinical and clinical program. Thus the GPA as a measure of student performance in conducting the curriculum is expected to correlate in&nbsp; achieving the “UKMPPD CBT”.</p> <p>Aims: To determine the correlation between preclinical GPA score of students with achieving the “UKMPPD CBT”.&nbsp;</p> <p>Methods: It was cross sectional design consisting subject of 749 students who joined “UKMPPD CBT” as firstaker since November 2014-February 2018. Data obtained were preclinical GPA and the results of “UKMPPD CBT”. GPA data was grouped into three categories with satisfying, very satifying, and cum laude predicate. The results of “UKMPPD CBT” were grouped by achieving and not achieving. Furthermore, the data was analyzed using Sommers'd correlation test.</p> <p><strong>Results:</strong> The median value of preclinical GPA were 3.00 (2.35-3.76). There is a weak negative correlation between preclinical GPA with achieving of “UKMPPD CBT” (p &lt;0.001; value r = -0.221).</p> <p><strong>Conclusion:</strong> There is a weak negative correlation between GPA with the accomplishement of UKMPPD CBT. This result can provide feedback to institutional managers regarding the process of implementing the curriculum based competency.</p> Dian Ayu Hamama Pitra, Resti Rahmadika Akbar Copyright (c) 2019 International Journal of Medical Science and Clinical invention Mon, 15 Apr 2019 10:01:10 +0000 High Expression of CXCR4, Instead of PD-L1, Is Correlated with Poor Clinical Response to R-CHOP Therapy in Diffuse Large B-cell Lymphoma Patients <p><strong>Background:</strong> Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin Lymphoma worldwide. Rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine and prednisone (R-CHOP) are the current standard therapy. About 10% cases of DLBCL were refractory to these immunochemotherapy and may have poor prognosis. Latest studies showed that C-X-C chemokine receptor type 4 (CXCR4) and Programmed Death Ligand 1 (PD-L1) were involved in DLBCL biology and correlated with patients’ poor survival. This study aimed to investigate the expression of CXCR4 and PD-L1 with clinical characteristics and its response to R-CHOP in DLBCL and their potential benefit as future predictive biomarkers.</p> <p><strong>Methods:</strong> Thirty four cases of newly diagnosed DLBCL were selected from Hasan Sadikin General Hospital, Bandung, Indonesia, during 2015-2018. Treatment outcome was retrieved from patients’ medical records. The expression of CXCR4 and PD-L1 in patients’ tumor &nbsp;tissues were detected using immunohistochemistry.</p> <p><strong>Results: </strong>Five of 34 cases (14.70%) showed poor clinical response to R-CHOP. High CXCR4 expression was detected in 11 of 34 cases (32.35%), it was significantly correlated with clinical stage (p = 0.0003) and poor clinical response (p = 0.029). High PD-L1 expression was detected in 10 of 34 cases (29.41%) and was significantly correlated with patients’ gender (p = 0.022) but was not correlated with poor clinical response (p = 0.138).</p> <p><strong>Conclusions: </strong>CXCR4 in DLBCL increased probability of poor clinical response to R-CHOP, but not PD-L1 expression. This finding provides the ground for further research which relates to &nbsp;CXCR4 as a future predictive biomarker for this challenging malignancy.</p> fety Riani, Birgitta Maria Dewayani, Herry Yulianti, Bethy Surjawathy Hernowo, Sri Suryanti Copyright (c) 2019 International Journal of Medical Science and Clinical invention Thu, 18 Apr 2019 11:15:30 +0000 Utility of Rapid urease test in diagnosis of Helicobacter pylori infection <p><strong>Aim</strong>: To evaluate the role of rapid urease test in diagnosis of Helicobacter pylori infection in various gastro intestinal lesions vis a vis conventional and special staining methods.</p> <p><strong>Materials &amp; Methods:</strong> This hospital based cross sectional study was conducted on 50 cases with gastro intestinal lesions. &nbsp;The obtained biopsies were then subjected to rapid urease test for detection of H. pylori by using the Pronto Dry Kit immediately. Further histopathology examination using conventional H &amp; E (haematoxylin and eosin) stain and special Gimenez stain for H. pylori was done.</p> <p><strong>Results:</strong> In this study gender wise distribution of patients showed 58% males and 42% females. Chronic gastritis was found to be the most common diagnosis (28%), followed by squamous cell carcinoma (20%) chronic inflammation (16%), H. pylori gastritis and adenocarcinoma stomach (6%), adenocarcinoma esophagus, dysplasia, erosion, esophagitis and perforation in 4%. Least common diagnosis was atrophic gastritis and carcinoid in 2%. We found that 26 cases were positive for H. pylori with Rapid urease test and 24 with special stain (Gimenez).</p> <p><strong>Conclusion: </strong>This study amalgamates and incorporates the valuable clinical assessment along with the endoscopic findings, the surgical pathological (histopathology) evaluation of the biopsies along with the proto dry kit (rapid urease test), as a kind of “Gastric Triple Test” for declaring the patients as positive or negative for pathogenic infection with Helicobacter pylori.</p> Shaan Khetrapal, Samarth Shukla, Safia Rana, Zeeba S Jairajpuri, Sourya Acharya Copyright (c) 2019 International Journal of Medical Science and Clinical invention Thu, 18 Apr 2019 11:25:34 +0000 Assesment of Depression in Patients Having Chronic Obstructive Pulmonary Disease <p>Depression in COPD patients is one of commonest problem arising now a days. Most of patients are affected by severe depressive symptoms or clinical depression. It is not easy to diagnose depression in COPD patients because of overlapping symptoms between COPD and depression. Quality of life is strongly impaired in COPD patients and patient’s quality of life emerges to be more correlated with the presence of depressive symptoms than with the severity of COPD.&nbsp; In this study four-item Hamilton Depression Subscale appears to be a useful screening tool. &nbsp;In patients with milder depression, pulmonary rehabilitation as well as cognitive-behavioral therapy are effective.&nbsp;</p> Dr. Rohit S shukla, Dr Mamta Shukla Copyright (c) 2019 International Journal of Medical Science and Clinical invention Mon, 29 Apr 2019 10:05:21 +0000 The role of MDCT in the diagnosis of small bowel obstruction secondary to multiple adhesion bands: A case report <p>Adhesion band is a major cause of small bowel obstruction. Traditionally, the obtained results of computed tomography (CT) scan were indicative of adhesion band as an etiology for small bowel obstruction. However, adhesion is easily diagnosed today due to technological advances in radiology and high-quality multidetector CT. It is important to avoid the possible complications of bowel obstruction in the early and appropriate surgical intervention. This article is a report of a 45-year-old woman with abdominal pain and history of previous abdominal surgery. A contrast-enhanced CT scan showed multiple adhesion bands ensued the abrupt narrowing of bowel diameter and closed small-bowel loops obstruction. Furthermore, multiple bands were clearly observed and adhesiolysis was performed in the surgery.</p> Farideh Gharekhanloo, Masoud Esnaashari Copyright (c) 2019 International Journal of Medical Science and Clinical invention Mon, 15 Apr 2019 10:06:40 +0000