International Journal of Medical Science and Clinical invention <p><strong>International Journal of Medical Science and Clinical invention</strong>&nbsp;is an international, peer-reviewed journal that welcomes original research articles and reviews on&nbsp;current advances in Medical sciences,&nbsp;preclinical&nbsp;and&nbsp;clinical medicine, and&nbsp;related disciplines.</p> <p>The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments.</p> <p><em>International Journal of Medical Science and Clinical invention&nbsp;</em>&nbsp;publishes articles which bring novel insights into&nbsp;diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on&nbsp;<strong>Clinical</strong>&nbsp;pathological sciences&nbsp;giving foundation knowledge on the overall study of human diseases. Through its publications&nbsp;<em>International Journal of Medical Science and Clinical invention</em>&nbsp;also stresses the importance of&nbsp;Medical sciences&nbsp;as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines.</p> en-US (Valley International) (Pawan lohar) Wed, 30 Oct 2019 00:00:00 +0000 OJS 60 Solitary Fibrous Tumor of the Female Pelvis – Clues to the Radiological Diagnosis <p>Solitary fibrous tumors were initially described in the pleural cavity and they were thought to have mesothelial origin. Nowadays, these tumors are known to have origin in the mesenchymal cells and they are ubiquitous with both pleural and extrapleural distribution. There are many extrapleural localizations, being the pelvis one of the rarest and the most challenging to diagnose. Usually, solitary fibrous tumors are clinically insidious and manifest as a slow-growing large tumor. At imaging, these tumors have different characteristics, and computed tomography and magnetic resonance play an important role in their diagnosis. Solitary fibrous tumors appear as heterogeneous enhancement on contrast-enhanced computed tomography, intermediate signal on T1-weighted images, hypointense on T2-weightes images and show intense heterogeneous enhancement in dynamic sequences. When they appear in the female pelvis, it is essential to recognize their radiological characteristics, in order to differentiate it from others tumors, like pure stromal ovarian tumors or Brenner tumors. This study reviews the female pelvis solitary fibrous tumors’ imaging findings and its differential characteristics from more common tumors, by describing illustrative confirmed cases.</p> Andreia Tereso Copyright (c) 2019 International Journal of Medical Science and Clinical invention Sat, 19 Oct 2019 00:00:00 +0000 Awareness and the use of evidence-based medicine resources among physicians <p><strong>Aim</strong>: to evaluate awareness and the use of evidence-based medicine resources among physicians in Jordan.&nbsp;</p> <p><strong>Method:</strong> A cross-sectional study by internet was performed among 517 doctors who were responsive from a total of 717 doctors, a total of 72.1% response rate. Doctors from all specialties were contacted from a Facebook group called doctors café in Jordan. A questionnaire was given to each one of them to measure their awareness and use of Evidence based database.&nbsp;&nbsp;</p> <p><strong>Result</strong>: From 517 physicians 377 they are using evidenced based resources frequently, and 91 using resources but not frequently and 49 not using evidence-based resources. The resource that was mostly used by the doctors was PubMed, followed by other resources such as Up to date, National Guideline Clearinghouse, Medscape, BMJ best practice, e-books and other online journals for published papers. The Cochrane Library was surprisingly not so familiar amongst physicians.</p> <p><strong>Conclusion:</strong> There is good awareness about EBM among physicians in Jordan, and that benefits health care in Jordan.</p> Amjad Alhelo, Bashar Samara Copyright (c) 2019 International Journal of Medical Science and Clinical invention Sun, 13 Oct 2019 00:00:00 +0000 Effectiveness of self-instructional module on knowledge regarding Attention Deficit Hyperactive Disorder among primary school teachers in selected schools of Gangtok Sikkim <p>Attention Deficit Hyperactive Disorder is a common behavioural disorder that affects about 10% of school age children. About 7% children worldwide have Attention&nbsp; Deficit Hyperactive Disorder. In rural India population, the prevalence of&nbsp; Attention Deficit Hyperactive Disorder is 3.66%. The main aim of the study was to find out the effectiveness of self-instructional module on Attention Deficit Hyperactive Disorder. The investigators adopted a pre-experimental research design among seven selected schools through simple random sampling.A total of 80 primary school teachers were selected using the purposive sampling technique. Self-instructional module and structured knowledge questionnaire was prepared and sent&nbsp; for validation. Pretesting and reliability was done and found reliable(r = 0.8). Firstly, pretest session was conducted using structured knowledge questionnaire to assess the knowledge of primary school teachers on Attention Deficit Hyperactive Disorder. Self- instructional module(SIM’s) was administered 4 days after the pretest session. After 14 days of SIM’s distribution, posttest was conducted to assess the effectiveness of self-instructional module. The findings reveal that majority 60% of primary school teachers have average knowledge in the pre-test and 86.25% had good knowledge in the post-test. The calculated paired ‘t’ test value ‘t = 11.259’ was found to be statistically significant at p&lt;0.05 level. The study concluded that educational material in the form of self-instructional module helped the teachers to improve their knowledge on Attention Deficit Hyperactive Disorder. The gained in the knowledge from the Self-instructional module will help them to identify and manage children with Attention Deficit Hyperactive Disorder in future.</p> Lireni Tungoe, Arkierupaia Shadap, Prerna Karki Copyright (c) 2019 International Journal of Medical Science and Clinical invention Sun, 13 Oct 2019 00:00:00 +0000 Correlation of ACTH and Salivary Cortisol levels to diagnose Adrenal Insufficiency in cirrhotic patients. <p><em>P</em><em>u</em><em>r</em><em>po</em><em>s</em><em>e</em>. The prevalence of adrenal insufficiency (AI) in patients with decompensated liver cirrhosis is unknown. Because these patients have lower levels of cortisol-binding carrier proteins, their total serum cortisol (TSC) correlates poorly with free serum cortisol (FC). Salivary cortisol (SaC) correlates better with FC. We aimed to establish SaC thresholds for AI for the 250 g intravenous ACTH test and to estimate the prevalence of AI in non-critically ill cirrhotic patients. <em>M</em><em>ethods</em>. We included 39 patients with decompensated cirrhosis, 39 patients with known AI, and 45 healthy volunteers. After subjects fasted ≥8 hours, serum and saliva samples were collected for determinations of TSC and SaC at baseline 0’ (T0) and at 30-minute intervals after intravenous administration of 250</p> Dr Haris Memon, Dr. Muhammad Haroon Mujtaba Memon, Dr. Mahum Shahab, Dr. Mahmood Iqbal, Dr. Ghulam Murtaza Memon Copyright (c) 2019 International Journal of Medical Science and Clinical invention Thu, 31 Oct 2019 02:40:48 +0000 Environmental factors and life style having an impact on pathogenesis and etiology of Diabetes Mellitus <p><span class="Bodytext7"><span style="font-size: 8.5pt;">Type 2 diabetes mellitus (T2DM) is currently a public health problem worldwide and a threat to human health and social development. The incidence rate of the disease is steadily increasing. Various genetic and environmental factors have been established as influencing the pathogenesis of this disease. However, the influence of social factors and the natural environment on DM incidence should also be considered. Low-grade inflammation could represent a central point of connection integrating all these potential triggers, being partly responsible for the development of insulin resistance. This paper aims to elaborate on the impact of the natural environment and social factors on DM development, with a special focus on six aspects of the pathogenesis of DM: pollution, radiation, psychology, drink, sleep, and exercise. We identified a two-way relationship between T2DM and social and natural environments. Changes in these environments may lead to low-grade inflammation, which in turn induces or aggravates T2DM and vice versa. Poor lifestyle may lead to increased insulin resistance and promote DM development. Improvements in blood glucose control can be achieved through non-environmental and behavioral interventions.</span></span></p> Rajesh Kumar, Prinka perswani, Aurangzeb memon, Syeda Moazzama Zaidi, Rajna kumari Copyright (c) 2019 International Journal of Medical Science and Clinical invention Thu, 31 Oct 2019 02:46:34 +0000 Association of Chemerin with Complications in type 2 diabetic patients. <p><span class="Bodytext7"><span style="font-size: 10.0pt;">Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found to exert a major role in glucose and lipid metabolism. The aim of this study was to explore the correlation between plasma Chemerin levels and microangiopathy in patients with T2DM. </span></span><span class="Bodytext78pt"><span style="font-size: 10.0pt;">Methods.</span></span><span class="Bodytext7"><span style="font-size: 10.0pt;"> A total of 598 T2DM patients were classified into two groups: with and without micro vascular complications. Anthropometric parameters and blood pressure were taken. The amounts of glycosylated hemoglobin, glucose, lipid profiles, creatinine, and Chemerin concentrations in the blood were determined. The presence and severity of nephropathy, retinopathy, and neuropathy were also evaluated by specific tests. </span></span><span class="Bodytext78pt"><span style="font-size: 10.0pt;">Results.</span></span><span class="Bodytext7"><span style="font-size: 10.0pt;"> Plasma levels of Chemerin in diabetic subjects with micro vascular complications were markedly elevated compared to those without. The number of micro vascular complications increased with high plasma Chemerin levels. Patients with high Chemerin levels had an increased incidence of nephropathy and retinopathy. Furthermore, the Chemerin plasma concentrations increased with the progression of diabetic nephropathy with highest values in macro albuminuria groups. In contrast, no significant difference was observed in plasma Chemerin levels between subjects with and without peripheral neuropathy. Pearson correlation analysis showed that plasma Chemerin levels were positively related to duration of diabetes, serum creatinine, and 24-hour urine albumin excretion, even after multiple adjustments. Using logistic regression analysis, plasma Chemerin concentrations were independently associated with the presence of nephropathy and retinopathy, not neuropathy. </span></span><span class="Bodytext78pt"><span style="font-size: 10.0pt;">Conclusion.</span></span><span class="Bodytext7"><span style="font-size: 10.0pt;"> This study elucidated a positive correlation between increased Chemerin levels and the development of some subtypes of diabetic microangiopathy.</span></span></p> Prinka perswani, Rajesh Kumar, Ram Sandesh, Syeda Mehak Fatima, Syeda Moazzama Zaidi Copyright (c) 2019 International Journal of Medical Science and Clinical invention Thu, 31 Oct 2019 02:53:01 +0000 Retained Intra Uterine Contraceptive Device in a thirty year old woman leading to secondary infertility <p>The use of Intra-Uterine contraceptive device (IUCD) had been found to be associated with several complications such as bleeding, perforation or migration into surrounding tissues or the omentum and retention. This is a case of a 30-year-old woman who had insertion of IUCD six years before presentation in the clinic which was believed to have been removed. However, uterine ultrasound showed that the IUCD was retained. She then presented with inability to achieve pregnancy of three years duration despite adequate unprotected sexual intercourse. She had Intra-Uterine contraceptive device inserted six years before presentation which she said a Doctor at a private hospital had removed two years after insertion. Her last confinement was about six years before presentation. However, uterine ultrasound showed a normal-sized uterus containing an Intra-Uterine contraceptive device. The retained IUCD was subsequently removed by dilatation and curettage and the patient became pregnant two months later. With appropriate investigation, in this case, accurate ultrasound, it was possible to locate the IUCD and subsequently removed it to solve the patient’s problem.</p> Ismaheel A. Azeez, Lawrence A Adebusoye, Jamiu A Lasisi, Banke I. Yusuf Copyright (c) 2019 International Journal of Medical Science and Clinical invention Mon, 21 Oct 2019 00:00:00 +0000