International Journal of Medical Science and Clinical Invention

Retrospective Study of Various Factors In Pediatric To Severe Dengue Infection

Mohammad Sazzad Hossain Chowdhury, Md. Obaidul Islam, Md. Asaduzzaman — Thu, 04 Apr 2024 00:00:00 +0000

Introduction: Dengue epidemics are known to have occurred over the last three centuries in tropical, subtropical and temperate areas of the world. Annually a 100 million cases of Dengue fever and half a million cases of dengue hemorrhagic fever (DHF) occur in the world with a case fatality in Asian countries of 0.5%–3.5%. Objective: To assess the various factors in pediatric to severe dengue infection. Methods: A hospital-based Retrospective study was conducted at Department Of Paediatric, Mugda Medical College Hospital, Dhaka, Bangladesh from October to December 2023. Number of patients included in the study was 50. In children with high degree clinical suspicion of Dengue infection NS 1 antigen (who came within first 48 hours of fever) and/or Dengue antibody IgM, IgG (who came after five days of fever) were performed. Positive Dengue cases were taken written informed consent & interviewed on the risk factors of Dengue infection. Data related to patients demography, risk factors, clinical presentation, pattern of Dengue infection and outcome were documented on the pre-structured questionnaire. Results: The study was enrolled 100 patients of suspected dengue fever of whom 50 (50.0%) were serologically confirmed to have dengue infection. 30 (60%) patients were males and 20 (40%) were females. 38 (76%) patients had classic dengue fever while 12 (24%) fulfilled the criteria of dengue hemorrhagic fever. Of those patients with dengue hemorrhagic fever, 6 patients had developed dengue shock syndrome. Among the study 44 (88%) from urban and 6 (12%) rural area patients. All cases and is the most common symptom followed by headache, myalgia, vomiting etc. Hemorrhagic manifestations were seen that included petechiae, ecchymosis, gum bleeding, hematuria, malena, hematemesis and epistaxis. Most common complicationswere hepatic dysfunction, renal failure, multi organ failure, encephalopathy and ARDS. Among 50 suspected dengue cases 38 (76.0%) cases were serologically dengue positive. Among the 38 serologically dengue positive patients 17 (44.7%) were NS1 antigen positive, 13 (34.2%) IgM antibodies and 8(21.0%) both IgM and IgG antibodies positive. The distribution of the serologically dengue positive patients out of 50 clinically suspected cases. Conclusion: Dengue is one amongst the key causes of dedifferentiated fever. It presents as an extremely broad wellness and is hardly recognized as a clinical entity by primary health care physicians. This study highlights the practician the importance of break bone fever to clinicians within the areas of medical specialty, manifestations, complications and outcome of the wellness

Topical application of vitamin D cream in particiants with inflammatory acne due to vitamin D deficiency

Lana Lekic, Bojan Pavlovic — Fri, 12 Apr 2024 00:00:00 +0000

Acne vulgaris (AV) represents a chronic inflammatory condition affecting pilosebaceous units, characterized by a multifactorial etiology. AV can manifest as both inflammatory and non-inflammatory skin lesions. Non-inflammatory acne is termed a comedone, which can be either closed (whiteheads) or open (blackheads). Inflammatory acne encompasses papules, pustules, nodules, and pseudocysts. The most common regions for acne occurrence are the facial region (90%), thoracic area (14%), and dorsal region (60%). In the study involving transdermal application of vitamin D cream (applied twice daily; morning and evening) in subjects with inflammatory acne due to vitamin D deficiency, 33 participants took part, comprising 8 males and 25 females. The age group most affected was 18-25 years (adolescent age), followed by a lesser impact in the 26-30 age group, and the lowest incidence observed in the late 36-45 age group. Among males, facial and thoracic regions were most affected by inflammatory acne (37.5%), while among females, the facial region showed a higher percentage of 54%, and the thoracic area was at 40%, with a minimal impact on the dorsal region (M=25%; F=8%). Reductions in inflammatory acne ranged from 100% to 10%, with substantial improvements noted in the male population, achieving 100% and 80% reduction (100% reduction: facial region 25%, thoracic area 12.5%, 80% reduction: dorsal region 25%). Similarly, the female group, with a larger sample size (25 participants), demonstrated significant reductions (100% reduction: facial region 36%, thoracic area 24%, 80% reduction: dorsal area 4%). Overall, improvements were evident in all participants, with none falling below a 30% reduction, indicating remarkable outcomes after one month of vitamin D cream use. Numerous factors contribute to the onset of inflammatory acne, with this study specifically highlighting vitamin D deficiency in the blood. Other indications include the occurrence of polycystic ovaries and reduced thyroid function in women, heightened stress, and prostate issues in men. Reduced or deficient vitamin D levels may be associated with further immune system suppression, activating the aforementioned factors. This research marks a significant stride in uncovering the manifold health benefits of vitamin D.

Keywords: acne, vitamin D, participants

Acute Ischemic Stroke and Metabolic Syndrome Comorbidity

Sefer Varol — Mon, 22 Apr 2024 00:00:00 +0000

Aim

Cerebrovascular diseases (CVD) lead to serious disabilities and loss of labor in societyin addition to mortality. Metabolic syndrome (MetS) is a group of known metabolic risk factors such as high blood pressure, dyslipidemia, glucose intolerance, or high blood sugar, due to insulin resistance.

The present study aimed to investigate MetS and its components in acute ischemic stroke patients and analyze these components as risk factors.

MATERIAL-METHOD

The study was conducted with 80 patients, 46 males and 34 females, who were admitted to the Taksim Training and Research Hospital Neurology Clinic with acute ischemic stroke diagnosis between April and October 2007 within the first 48 hours of the disease onset. The presence of MetS was investigated in 80 patients, including large artery atherosclerosis (BAA), small artery occlusion (CAO), and cardioembolic disease (CE).

FINDINGS

MetS was determined in 48 patients out of 80. TheMetSpresence rate was 60%. The analysis of the MetS rates in disease groups revealed that the highest rate was in 30 of 39 BAA patients (76.90%). The mean MS criterion count was statistically significantly higher in theBAA group when compared to the CE and CAO groups. A statistically significant difference was determined between the abdominal obesity distributionsin BAA, CE, KAO groups. A statistically significant difference was determined between the MS presence in the BAA, CE, CAO groups.

CONCLUSION

Certain modifiable stroke risk factors are included in a cluster of risk factors called MetS. Efforts to reduce theMetS parameters could be effective in stroke prevention.

Solar Alpha Particle Radiation Increases Human Mortality – an example from the HIV disease mortality in the European Union

Nikolay Takuchev — Mon, 22 Apr 2024 00:00:00 +0000

A dangerous phenomenon for humanity is described. In the joint analysis of data from satellites in orbit around the Earth and from the health statistics source EUROSTAT, it became clear that, by some mechanism, flows of positively charged particles with high energy entering the Earth's orbit increase mortality on the planet's surface. The increase in mortality is in a zone of maximum risk in the Northern Hemisphere, parallel to the equator and bounded by the parallels of 30° and 50° north latitude. Examples are given for the European Union mortality from HIV disease confirming the described phenomenon. A hypothetical mechanism based on observational evidence has been proposed, according to which this dangerous phenomenon is due to solar alpha particles of high energy sufficient to overcome the atmosphere's resistance and reach the Earth's surface in a limited area of maximum death impact.