Introduction: The ability of modern technology to substitute for life threatening respiratory failure is the signature technology of intensive care medicine where mechanical ventilation has played a primary role. The main aim for Mechanical ventilation should be to provide for supportive life support with least risk to the patient. The aim of this study was to study the clinical outcomes and its determinants in mechanically ventilated patients in ICU.

Methods : This prospective observational study was conducted in the medical ICU of Pondicherry Institute of Medical Sciences, Pondicherry, during the period from august 2013 to august 2015.Primary objective was to determine the In–hospital outcomes and 30 day survival of non surgical patients receiving mechanical ventilation and secondary objective to determine the association of demographic factors with In-hospital outcome and 30 day survival of non surgical patients receiving mechanical ventilation.

Results: 245 patient were included in the study of which 168 (68%) were males and 77 (32%) were females. Most common diagnostic group for admission to ICU was Respiratory infections accounting for 32%.Of the 245 patients , 53 (22%) patients died during hospital stay and 40(16%) discharged against medical advice .Of the 152 patients discharged 12 (7%) died at home after discharge.126 (51%) patients were alive post discharge after 30 days .87 (36%) patients developed VAP.APACHE II score was independently associated with 30 day mortality.

Conclusion: APACHE II scoring is one of the most important determinants of 30 days survival in mechanically ventilated patient. Hence APACHE II scoring can used to find the high risk patients and special care should be focused on these patients.

Kiran G Kulirankal