Articles | Open Access
Vol. 5 No. 4 (2018)
|
Page No.: 3729-3733 |
https://doi.org/10.18535/ijmsci/v5i4.03
Department of Clinical Pathology, Affiliated Dongguan Houjie Hospital, Guangdong Medical College, Dongguan, Guangdong523945, China
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Dujuan Wang
Department of Clinical Pathology, Affiliated Dongguan Houjie Hospital, Guangdong Medical College, Dongguan, Guangdong523945, China
Department of Clinical Pathology, Affiliated Dongguan Houjie Hospital, Guangdong Medical College, Dongguan, Guangdong523945, China
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Li Chen
Department of Clinical Pathology, Affiliated Dongguan Houjie Hospital, Guangdong Medical College, Dongguan, Guangdong523945, China
Department of Clinical Pathology, Affiliated Dongguan Houjie Hospital, Guangdong Medical College, Dongguan, Guangdong523945, China
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Lihua Zeng
Department of Clinical Pathology, Affiliated Dongguan Houjie Hospital, Guangdong Medical College, Dongguan, Guangdong523945, China
Department of Clinical Pathology, Affiliated Dongguan Houjie Hospital, Guangdong Medical College, Dongguan, Guangdong523945, China
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Shuzhen Han
Department of Clinical Pathology, Affiliated Dongguan Houjie Hospital, Guangdong Medical College, Dongguan, Guangdong523945, China
Abstract
Breast cancer is a malignant tumor that seriously affects females’ physical health, which is the leading cause of cancer death among Chinese female. Estimating early diagnostic and prognostic markers are helpful to conduct treatment for patients with breast cancer. Accumulating investigations focused on the role of Jab1 and S100A8 proteins in the development and metastasis. In our study, we performed the immunohistochemical stain for Jab1 and S100A8 in breast carcinoma and para-carcinoma samples. We have found that the positive rate of Jab1 and S100A8 in breast cancer was higher than that in para-carcinoma tissues. The expression level of Jab1 and S100A8 in breast cancer might have a close relationship with the histologic grade and lymphatic metastasis. The two proteins might be promising supplementary targets for the treatment and prognosis of breast cancers in clinical pathology.
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