Actinic keratosis (AKs) are dysplastic lesions limited to epidermal keratinocytes and are considered squamous cell carcinomas in situ. AKs affect individuals who have had chronic exposure to sunlight, particularly those with skin types 1 or 2 on the Fitzpatrick phototype scale. In this clinical trial topical therapy with diclofenac gel was demonstrated to be safe and effective overall for the treatment of actinic keratosis. A resolution of at least 50% of lesions was observed in 78% of patients with a high level of satisfaction in 85% of cases.