Abstract

Drug discovery process is a long drawn time and resource consuming process. The conventional drug discovery process involves potential lead from either traditional system of medicine or from the in vitro experiments leading to a lot of animal experimentations wahich culminates in human trials. These whole processes usually take years of time and resources. Many a times, when a drug accreditation is accorded, the pharmacoeconomic values outnumbers the drug addition value to the drug library. With the advent of the usage of computers in biology, the discovery process shortened with the help of uniform and defined in silico parameters, thus providing an alternative to the laborious and variable in vitro experiments. While, this was a welcome move in the field of drug discovery but simultaneously it also opened the flood of potential molecules which often matched the defined in silico parameters but provided variable results in in vivo experiments. This article provides an overview of the drug discovery processes and its efficacy with a check on pharmacoeconomic values. The system of selection of potential lead molecule is based on several parameters out of which the most important aspect is that it should have no toxicity in vivo