Dr Bipul Ch Kalita,Dr Avisek Chakravort ty,Dr Juma Das,Dr Swarup Kar, Dr Dharmistha Basu
Fahr’s Syndrome: Rare Cause Of Parkinsonism- A Case Report
Dr Bipul Ch Kalita,Dr Avisek Chakravort ty,Dr Juma Das,Dr Swarup Kar, Dr Dharmistha Basu
A 63 years old male presented with progressive decline of motor functions and characteristic resting ‘pill rolling’ tremor of bilateral upper limbs. CT scan brain showed diffuse cerebral atrophy with bilateral cerebellar vermis, basal ganglia and parietal lobar calcification. The clinical and radiological features in this case suggested the diagnosis of Fahr’s syndrome.
Ovarian neoplasms have become increasingly important not only because of the large variety of neoplastic entities but more because they have gradually increased the mortality rate due to female genital cancers .A total of 56 cases of ovarian tumours were studied at the Department of Obstetrics and Gynaecology, Government Medical College and Rajindra Hospital, Patiala during the period January 2016 to June 2017 to find out the frequency of different histological patterns of ovarian tumours. Among 56 cases, 35 (62.5%) were malignant and 21(37.5%) were benign. The common histological pattern observed in the study was epithelial tumours. The commonest benign tumor was serous cystadenoma, while ; the commonest malignant tumour was mucinous cystadenocarcinoma. Maximum number of benign tumours were in age group 21-40 years. All malignant tumours were in age group 41-60 years. Vague complaints like pain lower abdomen, back pain were the presenting symptoms.
Dr Imtiyz Ahmed , Dr Nida Fatima , Prof. Tariq Mansoor , Dr Pankaj Singh
A study on the role of receptor (ER,PR,HER-2/neu) in patients of carcinoma breast
Dr Imtiyz Ahmed , Dr Nida Fatima , Prof. Tariq Mansoor , Dr Pankaj Singh
Objective: To evaluate the expression of HER-2/neu, estrogen receptor (ER) and progesterone receptor (PR) in breast carcinomas. Methods: This was a prospective hospital based study conducted on patients of carcinoma breast. The study population comprised of patients who were diagnosed to have carcinoma breast on the basis of preliminary Trucut biopsy/ open biopsies, and subsequently underwent surgery for the disease. All patients who had undergone previous chemo or radiotherapy were excluded from the study. A total of 72 patients were included in the study. Results: About one third of patients were between 41-50 years of age (30.6%). TNM stage IIIB was among in 30.6% patients and IIIA was in 25%. Tumor grade III was among more than half of patients (61.1%). Infiltrating ductal carcinoma was among 88.9% patients. ER and PR was positive in 41.7% and 25% patients respectively. ER-/PR- was among 54.2% patients. HER2neu was positive in 22.2% of the patients. Luminal A and B was in 36.1% and 13.9% patients respectively. Conclusion: Breast cancer in Indian patients has been found to be histologically aggressive, presents at a younger age, and is less likely to be susceptible to conventional hormonal and targeted antibody treatment. Detecting and treating this increasingly important cause of mortality is an enormous challenge.
Angiographic study of double right coronary artery in Basra
Dr. Saja M. Ali , Dr. Hassna B. Jawad
Abstract: Splitting right coronary artery is a benign entity but the atherosclerotic changes once occurred the patient presented with acute coronary disease and even death . It is a very rare coronary artery anomaly and discover incidentally during cardiac angiography or autopsy . Here the pathological and clinical scenarios of this anomaly should be taken in account : Arrhythmia , heamodynamic and cardiac surgery procedures. Aim of study: To know the incidence of splitting or double right coronary artery among people in Basra by conventional coronary angiography. Patients and Methods: Prospective study of coronary angiography carried out in Basra cardiac center at Al- Sadder teaching hospital . A sample of 150 patients attended to cardiac center with acute coronary disease . Results : In our study the incidence of double right coronary artery was 3.3% and the mean length of anterior right coronary artery was 81.43 ± 2.22 mm and the caliber of this artery was 2.96 ± 0.76 mm while the mean length of posterior right coronary artery was 105.33 ± 3.36 mm and its caliber was 3.03 ± 0.732 mm. Conclusion : Double right coronary artery is a benign coronary artery anomaly but it may be life threatened if it associated with other congenital heart anomalies , atherosclerosis, arrhythmias or myocardial infarction.
Dr. Philip Koshy Vaidyan , Dr Gifty Marium George , Dr Mark Christopher.A
Clinical and Laboratory Profile of Patients Presenting With Warfarin Coagulation Abnormality Following Heart Valve Replacement- A Descriptive Study
Dr. Philip Koshy Vaidyan , Dr Gifty Marium George , Dr Mark Christopher.A
Despite revolutionary changes in the field of medicine and eradication or prevention of many diseases worldwide in the past few decades, rheumatic heart disease (RHD) still remains as one of the largest preventable disease burdens in the world and is seen to be more prevalent in the developing countries1 . Majority of RHD patients develop valvular heart disease with mitral valve incompetence as the most common valvular lesion seen in these patients2 . In symptomatic patients or those in whom evidence of impaired LV function at rest is seen, surgical intervention is the definitive treatment 3 . Patients who undergo surgical intervention may have either a bio prosthetic valve replacement or a mechanical valve replacement. Those in the latter group requires to be initiated on vitamin K receptor antagonist drugs like warfarin in order to prevent thrombus formation of the mechanical valves.
Luis Alfredo Gomez Vieira Thiago Batista Faleiro, Alexandre Vasconcelos de Meirll es , João Euripides de Alcantara Júnior
Bilateral clavicular hypoplasia and cleidocranial dysplasia: Case report
Luis Alfredo Gomez Vieira Thiago Batista Faleiro, Alexandre Vasconcelos de Meirll es , João...
Clavicular hypoplasia or agenesis is common in patients with cleidocranial dysplasia (CCD). CCD is an uncommon congenital pathology with an autosomal dominant pattern affecting males and females equally. CCD presents with wide phenotypic variability, but there is no stable link between the genotype and phenotype. In addition to clavicular hypoplasia/agenesis, such patients present with thoracic deformities, iliac hypoplasia, cranial bone deformities, and delayed dentition. An early diagnosis is important to determine treatment options. However, there is no specific orthopedic treatment for this disease.
Mohammed M. Jan1 , MB.Ch.B, FRCP(C) , Mohammed S. Alsallum2 ,Medical Student , Mark R. Sadler3 , MD, FRCP(C)
Transcranial Magnetic Stimulation and Epilepsy
Mohammed M. Jan1 , MB.Ch.B, FRCP(C) , Mohammed S. Alsallum2 ,Medical Student , Mark R. Sadler3 ,...
Transcranial magnetic stimulation (TMS) is a form of focal electrical brain stimulation where electrical currents are induced in the brain using a powerful magnetic field. TMS has been approved for the treatment of major depression using a specific high frequency repetitive TMS (rTMS) protocol. Recently, low frequency rTMS (0.3-1 Hz), resulted in lasting reduction in cortical excitability suggesting a potential therapeutic value for patients with intractable epilepsy. The risks of rTMS are minimal but include a small possibility of triggering seizures. In this paper we present a comprehensive updated review on the use of TMS for the treatment of epilepsy. We conclude that TMS has a potentially important therapeutic role and should continue to be evaluated in properly designed clinical trials.
Budi Yulhasfi Febrianto, Eddy Sutrisno , Frank Bietra Buchari , Utama Abdi Tarigan , Hidayat
The Polymorphism of Gene Reduced Folate Carrier 1 (RFC1) A80G Not Difference Between NSCLP Case and Control in Sumatera Utara, Indonesia
Budi Yulhasfi Febrianto, Eddy Sutrisno , Frank Bietra Buchari , Utama Abdi Tarigan , Hidayat
Cleft lip is the second most frequent congenital anomalies in Indonesia after Down Syndrome with the prevalence among children aged 24-59 months. The etiology of non syndromic cleft lip with or without cleft palate has not yet been defined. Some studies have investigated the involvement of genetic and environmental factors. Some genes involved in the folate metabolism have been recently examined in order to discover the genetic factors in the cleft lip etiology. This research intends to compare polymorphism in the Reduced Folate Carrier 1 A80G between subject with non syndromic cleft lip and palate (NSCLP) and control subject in the population of Sumatera Utara. In this case control study, 62 patients NSCLP and 61 controls underwent DNA isolation and genotyping process using Polymerase Chain Reaction – Restriction Fragment Length Polymorphism (PCR-RFLP).The distribution of genotype and allele variants between the case and control were not significantly different (p=0.271, p=0.809). In Conclusion, This research obtained the data that polymorphism RFC1 A80G mutant variant did not difference between case with NSCLP and control in the population of Sumatera Utara.
The Relationship Between the Duration of Cardiopulmonary Bypass (CPB) Use on Elevated Lactic Acid Post Operative of Open Heart Surgery at H. Adam Malik General Hospital Medan
Farhan Syarif, Marshal*, Doddy P. Pohan*
Introduction. Cardiopulmonary bypass (CPB) is widely used to regulate systemic perfusion and oxygenation during open heart surgery. During the use of CPB machines may be at risk of disrupting tissue perfusion and also after surgery is undertaken. The increase of lactic acid is a metabolic characteristic that results from the consequences of hypoxia, but this increase in lactic acid may also occur by a condition not caused by hypoxia. The purpose of this study was to investigate the relationship between CBP use and elevated lactic acid levels in patients with open heart surgery at RSUP H. Adam Malik Medan. Methods. This study used a design of correlative test research with retrospective approach.. The implementation of the study was conducted in the Division of Cardiothoracic and Vascular Surgery, Department of Surgery, Faculty of Medicine USU/ RSUP H. Adam Malik Medan. We studied patients undergoing open cardiopulmonary surgery using the Cardiopulmonary Bypass (CBP) at RSUP H. Adam Malik Medan in 2016, the data of CPB use and lactic acid values that met the inclusion criteria. Results. The number of research subjects was 30 people. Based on the results of the above study, any addition of CPB time more than 1 minute it will affect the increase in lactic acid 0.131 mg. The correlation between the duration of CPB and Lactic acid concentration with a large R value is 0.743. This indicated that there was a correlation between the duration of CPB and lactic acid concentration. Conclusion. Bivariatally there was a relationship between duration of CPB use and elevated lactic acid levels in patients with open heart surgery with r = 0.743. In this investigation there were several confounding factors controlled by patient selection and the same surgical technique.
Dr. Mitali Loya , Dr. Vaibhav Dubey , Dr. Himanshu Singh , Dr. Sanjeet Diwan
Acute and Transient Psychotic disorder and Schizophrenia: on a continuum or distinct? A study of phenomenology
Dr. Mitali Loya , Dr. Vaibhav Dubey , Dr. Himanshu Singh , Dr. Sanjeet Diwan
Background: The overview of epidemiology of Acute and Transient Psychotic disorder (ATPD) shows that it is wrong to assume that acute and transient psychotic disorder is somehow rudimentary or attenuated form of schizophrenia. Aims and Objective: This explorative study was designed to ascertain if there are any phenomenological differences between ATPD and cases of First Episode Schizophrenia (FES). Materials and Methods: A total of 60 patients (30 patients with ATPD and 30 FES patients) were enrolled. Illness-related variables were rated with the Brief Psychiatric Rating Scale (BPRS) at the time of first encounter and the frequencies of occurrence of various symptoms were compared between the two groups. Result: The two disorders appear to be different on the basis of phenomenology as affective symptoms and symptoms pertaining to increased PMA were found more frequently in the ATPD group, whereas, all the typical schizophrenic symptoms (delusions, hallucinations, disorganized behavior, speech and negative symptoms) were found to be more in the patients with FES.
