Abstract

Purpose: To evaluate the responses of clinical symptoms and prostate specific antigen (PSA) follow up in advanced stage prostate cancer patients in one year of hormonal therapy

Materials and Methods: We reviewed medical records of advanced prostate cancer patients consisting of age, clinical symptoms, digital rectal examination (DRE), PSA levels,  Gleason Score (G S) – histopathology grading, bone scan and hormonal therapy, follow up of clinical symptoms and PSA levels in one year of hormonal therapy in Arifin Achmad Regional General Hospital, Pekanbaru, Riau Province, Indonesia. Statistical analysis of univariate was used. Approval on the study was obtained from the Ethical Review Board for Medicine and Health Research, Medical Faculty, University of Riau.

Results: There were 36 advanced stage cancer patients in this study in which mostly (36.1%) in 51-60 and 61-70 year age groups.  Most (52.8%) clinical symptom was urinary retension and most (69.4%) DRE was abnormal. Initial PSA levels were mostly (52.8%) > 100 ng /ml. All histopathology findings were adenocarsinoma and the Gleason Score (GS) with histopathology grading were mostly (63.9%) 8 -10 with poorly differentiated. Bone scan showed metastases in 69.4% patients. Management was mostly (63.9%) Androgen Deprivation Therapy. The clinical symptoms was least found until nine months and PSA levels also were normal in nine months of follow up after hormonal therapy.

Conclusion: We found well responses of clinical symptoms and PSA follow up in advanced stage prostate cancer patients in one year managed by hormonal therapy.