Abstract

The primary skeletal lymphoma is a rare disease that accounts for only 0.5% of all extra nodal, The pathogenesis of the lymphoma that occurs in the muscles is not clear. It has been suggested that the muscle lymphoma may originate from abnormal lymph nodes within the muscles. In this report , there is a case  about this rare non-hodgkin lymphoma. A 42-year-old female patient presented to our clinic with complaints of pain in the left leg. In the bone biopsy from the lesion of the patient; it is seen that atypical cells with diffuse infiltration into adjacent striated muscle tissue The findings were evaluated as diffuse large B-cell lymphoma.  Primary extra nodal lymphomas in the skeletal muscle are radiologically similar to osteomyelitis, so in the case of a patient complaining of pain and swelling in the adjacent skeletal muscle, primary extra nodal lymphoma should be considered in differential diagnosis, although it is rare