Articles | Open Access
Vol. 6 No. 1 (2019)
|
Page No.: 4258-4262 |
https://doi.org/10.18535/ijmsci/v6i1.04
Vice President – Medical Services and Pharmacovigilance Centaur Pharmaceuticals Pvt. Ltd.
##plugins.generic.jatsParser.article.authorBio##
×
Dr. Mayuresh Dilip Kiran
Vice President – Medical Services and Pharmacovigilance Centaur Pharmaceuticals Pvt. Ltd.
Abstract
Introduction:
Glaucoma is a prevalent neurodegenerative disorder of the eye which can be characterised by increased intraocular pressure which leads to chronic, degenerative optic neuropathy. Fixed dose combination of Brimonidine 0.2%w/v and Timolol 0.5%w/v per ml can be used for the treatment of glaucoma due to elevated intraocular pressure (IOP).
Methodology:
Of total 150 enrolled patients, 125 patients completed the study and of 125 patients the clinical trial was conducted on 227 eyes. All the patients were asked to use the study fixed dose combination of Brimonidine 0.2%w/v and Timolol 0.5%w/v per ml twice a day. Efficacy assessment was done at visit 2 (day 10), visit 3 (day 20) and visit 4 (day 30) by analysing the reduction in the IOP as compared to baseline and safety assessment was done by recording and analysing the adverse events through the study.
Results:
At baseline the mean IOP was 27.659 which was decreased by 22.193% to 21.520 at visit 2 (V2), at visit 3 (V3) it was further decreased by 25.207% to 20.687 and at visit 4 (V4) the mean IOP was further decreased by 25.446% to 20.621.0. At V1 all 227 patients were having IOP>21 but at V2, V3 and V4; 134 (59.03%), 136 (59.91%) and 162 (71.36%) patients were having their IOP in the normal range i.e. IOP≤21.
Conclusion:
Fixed dose combination of Brimonidine 0.2%w/v and Timolol 0.5%w/v per ml is safe as well as efficacious for the treatment of glaucoma due to elevated IOP.
Downloads
Download data is not yet available.
Most read articles by the same author(s)
-
Dr. Mayuresh Dilip Kiran,
Shaheen Naseem Sheikh,
Lalit Jeevan Pawaskar,
Safety and Efficacy of a Zinc Gluconate Solution in Management of Paediatric Diarrhoea
,
International Journal of Medical Science and Clinical Invention: Vol. 5 No. 8 (2018)
-
Lalit Jeevan Pawaskar,
Dr. Mayuresh Kiran,
Ms. Shaheen Sheikh,
Ms. Pramita Waghambare,
Efficacy and Safety for the Combination of Neomycin, Beclomethasone, Clotrimazole and Lignocaine for the Treatment of Otitis Media with Perforation and Otitis Externa: Post-Marketing Surveillance Study
,
International Journal of Medical Science and Clinical Invention: Vol. 8 No. 07 (2021)
Copyrights & License
Copyright © 2019 Dr. Mayuresh Dilip Kiran Lalit Jeevan Pawaskar Ms.Pramita Waghambare Shaheen Nasreen Shekh this is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This work is licensed under a Creative Commons Attribution 4.0 International License.