Studies On Dissolution Rate Enhancement Of Etodolac In Solid Dispersions By Beta Cyclodextrin Complexes

Abstract

Etodolac is an anti-inflammatory drug that is poorly soluble in water. This paper describes an approach to improve the dissolution rate of Etodolac by using solid dispersions (SDs) in hydrophilic polymers. The solid dispersions were prepared with a Co-evaporation, kneading & Physical Mixture methods using different concentrations of β -cyclodextrin (β-CD). The release of Etodolac from various solid dispersions was determined from dissolution studies by use of USP dissolution apparatus II (paddle method). The dissolution study results revealed that there was a considerable increase in solubility and dissolution of all solid dispersions as compared to pure drug. Prepared Solid dispersions were characterized by differential scanning calorimetry (DSC), powder x-ray diffractometry (PXRD), and infrared spectroscopy (IR) and SEM images were evaluated for drug content, saturation solubility. Physicochemical characterization of solid dispersions suggests a reduction in drug crystallinity following dissolution enhancement. Results indicate that present %DE 30 of drug was improved from 36.01 to 82.49 by the use of Etodolac β-CDHPMC (1:2:0.3) Kneaded complex.