Neurologic Disease Caused By Toxic Followed By Immune Tolerance

Abstract

It’s a research which discusses immunological models of chemical tolerance, the potential role they may play in the aetiology of neurological autoimmune and neurodegenerative disease, and possible dietary approaches to mitigate the effects of these unfavourable responses. According to the immune model of chemical tolerance, small amounts of exposure to a variety of chemicals that are frequently present in our environment trigger exaggerated immune reactions that set off a chain reaction of immune dysregulation and systemic inflammation that results in neurological disease. Immune chemical tolerance is maintained by the healthy integration of different immune cells. This integration can be lost due to toxicant exposure, chronic stress physiology, blood-brain barrier compromise, intestinal barrier compromise, hormone imbalances, antigenic models, oxidative stress models, and other mechanisms. These pathways may be changed and controlled by a variety of dietary applications, it has been shown. Evidence-based consideration points to the potential role of various natural compounds with activity that can reduce the expression of NF-kappaB, optimise glutathione redox systems, improve barrier system impermeability, and support regulatory T-cell activity, all of which are crucial to improve chemical immune tolerance. There is an epidemic of toxicant load, and there are essentially no conventional or pharmaceutical strategies to decrease their impacts on human systems.