Abstract

Background and Objectives: Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae are a group of emerging highly drug-resistant Gram-negative bacilli causing infections associated with significant morbidity and mortality. KPCs are an important mechanism of resistance for an increasingly wide range of Gram-negative bacteria and are no longer limited to Klebsiella pneumoniae. KPC-producing bacteria are often misidentified by routine microbiological susceptibility testing and incorrectly reported as sensitive to carbapenems; The present study was undertaken to know the prevalence of KPC producing Klebsiella pneumoniae from clinical isolates and their antibiotic resistance pattern. Methods: A total of 76 Klebsiella pneumonia were recovered from various clinical specimens. All the samples were processed for routine bacterial culture and antimicrobial susceptibility test as per standard protocol. They were further subjected to KPC detection by Imipenem+ EDTA combined disc test and Modified Hodge test. Results: By Imipenem-EDTA combined disk test 26(34.21%) isolates were found to be KPC positive. By Modified Hodge test 23(30.26%) isolates were found to be KPC positive. Majority of KPC producers were resistant to Gentamicin (65.38%), Levofloxacin (84.61%), Piperacillin+Tazobactum(69.23%) and Norfloxacin (84.61%) respectively. All isolates were sensitive to Polymyxin B. Conclusion: The prevalence of Klebsiella pneumoniae Carbapenemases was 34.21% among Klebsiella pneumoniae. Significantly higher resistance rate was observed by these isolates to almost all the drugs routinely used

Downloads

Download data is not yet available.