Vitamin D Deficiency In Chronic Pancreatitis

Abstract

The main objective of this study was to determine the prevalence of 25OHD deficiency in patients with chronic CP, and to assess its relations to the contributing factors. Study encompassed 93 patients in two subgroups: 72 patients with proven CP (52% males; group mean-aged 52.7 years) and 21 matched control subjects (43% males, mean-aged 54.2 yrs) who consented to participate. CP patients were subdivided according to Cambridge classification for CT/MRCP (grade 1–4). 25-Hydroxyvitamin D (25OHD, sum of 25OHD3 and 25OHD2) was analyzed by a ID-LC-MS/MS method. Results: Vitamin D (25OHD) levels in CP patients were found lower than in the control subjects, p 0.036. Absolute 25OHD deficiency (values under 25nmol/L) was observed in 37.5% (27) of patients with CP, while the absence of deficiency (25OHD >80nmol/L) was found only in 8.3% (6). The mean 25OHD levels were found lower in patients with diabetes (vs non-diabetic) and those presented with Pancreatic Exocrine Insufficiency, p

<0.05. We found a difference between 25OHD mean values for subgroups 1- 4 by CT/MRCP, p><0.001. Seasonal difference in 25OHD status was significant for patients with Cambridge 1 and 2 grade (mild changes) and in the control subjects. In the opposite, the lowest 25OHD levels were registered for patients with severe imaging data Cambridge 3 and 4, without effect of season; p><0.005, odd Ratio 10.37. Conclusion: Most of our CP patients were with vitamin D deficiency and insufficiency and there was a strong relationship between 25OHD levels and severity of morphological imaging data with increased risk for 25OHD deficiency. >