One thousand, eight hundred and eighty four volunteers who reside in Iwollo community of Ezeagu Local Government Area of Enugu State, South East Nigeria were screened for ABO, Rhesus and Secretor blood groups. Group AB had the least percentage frequency in ABO distribution (2.96%) followed by group B (9.03%) then group A (40.03%) while group O had the highest percentage frequency of 47.98%. Group D +ve were 97.84% while D -ve were 2.16%. Secretors and non-secretors gave percentage frequencies of 78.03 and 21.97% of the subjects respectively