A retrospective study on lipid profile of patients having non-alcoholic fatty liver disease diagnosed by ultrasound in a tertiary care hospital

Abstract

Objective: To assess the lipid profile and body mass index (BMI) of the patients suffering from NAFLD in a north Indian population. Methods: This was a hospital based cross-sectional study conducted in a tertiary care hospital in north, India. All the ultrasound proven fatty liver cases without hepatitis, history of no alcohol intake and not on any lipid lowering medicine were included in the study. The patients with very low and high BMI, having diabetes and hypertensive were excluded from the study. A total of 128 patients were included in the study. The age, sex, height and weight were recorded. A detailed clinical history for all the patients was taken and careful general examinations were done. Ultrasonographic (US) examination of all the patients was done for diagnosing and classifying grades of fatty liver grades. Results: The mean age of the patients was 48.78±14.23 years and 45.3% of the patients were males. The mean BMI was 30.34±2.34. Increased levels of total cholesterol, triglyceride, LDL and VLDL were observed among NAFLD patients. HDL was found to be decreased among NAFLD patients. Majority of the patients were in Grade 0 (43.8%) followed by Grade I (32%), Grade II (17.2%) and Grade III (7%). Grade 0 fatty liver was higher among females (53.6%) than males (46.4%). Grade I fatty liver was also higher among females (58.5%) compared to males (41.5%). Conclusion: The study found abnormal profile of lipid levels amongst patients with fatty liver. A case-control study is recommended to find better understanding of lipid levels among NAFLD subjects.