Introduction: One of the complications of diabetes mellitus (DM) is peripheral neuropathy which among other effects causes loss of coordination of muscle groups in the foot, formation of callus which separates and an unclear easily infected by microorganisms appears. Objective: An attempt to establish the relationship between the bacteriology of the diabetic sores, the diabetic status of each patient, and the effect of the duo on sore healing was investigated. Method: Swab specimens of sores from 48 patients of both sexes (38 diabetic and 10 none-diabetic) was obtained for culture and sensitivity analysis. Every patient was placed on therapy which involved daily sore dressing, oral antimicrobial administration, and appropriate individualized anti-diabetic treatment. Each patients sore was evaluated two weeks after cessation of antimicrobial therapy. Results: A total of 48 isolates were recovered consisting of Staphylococcus aureus (62.5%), Echericia coli (20.8%), and Pseudomonas aeruginosa (16.7%). Antibiograms showed microbial resistance to ampicillin, penicillin G, tetracycline; partial sensitivity to chloroamphenicol, gentamycin, erythromycin, and septrin. Ciprofloxacin and ofloxacin were the most effective with as much as 100% sensitivity in vitro. The study found no disparity between diabetic sores and non-diabetic sores with regards to identity and sensitivity profiles of the isolated organism. The results of therapy and subsequent follow-up showed an overall 86.9% resolution of the sores 100% in the non-diabetic and 83.3% in the diabetics. A culture of the unresolved diabetic sores yielded no microbial growth indicating a corroboration between in vitro and in vivo sensitivity of isolated microorganism. Two of the diabetic with unresolved sore had attained normoglycermia. Conclusion: The study revealed that although infection and inappropriate wound care impede sore healing, hyperglycemia was undoubtedly the Achilles’ heel of patients with diabetic sores and concludes that optimum blood glucose control, effective wound care, and combating infection with antibiogram – based antibiotic therapy, are collectively of immense importance in the resolution of diabetic sores.