Abstract

Introduction: Upper Gastrointestinal tract endoscopy in combination with biopsy plays an important role in the early diagnosis of GI neoplasms and provides an opportunity for a broad range of treatment options as well as potential for possible cure. This study was done to determine the histopathologic spectrum of Upper Gastrointestinal Tract Mucosal Biopsies. Methods: A prospective study of upper GI endoscopic biopsy was carried out in a tertiary care hospital over a span of one year. 125 biopsy samples were subjected to histopathological examination. Result: Among the 115 endoscopic biopsies- oesophageal biopsies were 48 (41.7%), gastric biopsies were about 40(34.7%) and duodenal biopsies were 27 (23.4%). Male to female ratio was 1.44:1. Mean age of presentation was 40 years. Biopsies comprised of 78 (67.8%) non neoplastic cases and 37(32.1%) neoplastic cases. Among the 37 neoplastic cases,21 cases were from oesophagus and 16 cases from stomach. All the 21 esophageal malignancies were squamous cell carcinoma(SCC)and all the 16 gastric malignancies were diagnosed as adenocarcinoma. Conclusion: We conclude that endoscopy is incomplete without biopsy and so the combination of methods provides a powerful diagnostic tool for better patient management.