Abstract

The effects of co-administration of caffeinated paracetamol and artesunate on the liver enzymes Alanine aminotransferase, (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP), of guinea pigs were studied. The study is aimed at investigating the possible toxic potentials of Caffeinated paracetamol and artesunate on the liver enzymes of guinea pigs. 24 guinea pigs were used and divided into 4 groups with 6 guinea pigs in each group. Group 1 served as the control, group 2 was given caffeinated paracetamol and group 3 was given artesunate. While group 4 was given co-administration of caffeinated paracetamol and artesunate according to their respective body weight. The Liver enzymes of ALP, ALT and AST were estimated using TECO DIAGNOSTIC KIT. The results obtained were statistically analyzed using students T- Test distribution. When the ALT, AST and ALP levels (30.94±13.26)u/l, (19.15±9.43)u/l, and (37.50±6.92)u/l of the group 2 were compared with the ALT, AST and ALP levels (26.52±5.10)u/l, (29.46±19.54)u/l, and (35.42±6.98)u/l of the control group, there was no significant difference (P>0.05). When the ALT, AST and ALP (23.57±8.33)u/l, (25.05±14.81)u/l and (35.42±3.36)u/l of the groups was compared with the ALT, AST and ALP (26.52±5.10)u/l, (29.46±19.54)u/l and (35.42±6.98)u/l of the control group there was no significant difference (P>0.05). Finally when the ALT, AST and ALP (29.46±12.15)u/l, (20.63±8.33)u/l and (29.17±2.76)u/l, of the group 4 was compared with the ALT, AST and ALP (26.52±5.10)u/l, (29.46±19.54)u/l and (35.42±6.98)u/l of the control group of the guinea pigs, there was no significant difference (P>0.05). Study suggests there were no hepatotoxicity /or hepatocellular damage on the liver guinea pigs.