Abstract

Introduction:Inflammation is the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. The importance of inflammation in progression of casual disease is one of the factors for the use of anti-inflammatory drugs in clinical medicine. The main aim of this study is to assessthe anti-inflammatory properties of herbal plants. In this context, comparative study regarding anti-inflammatory effect of Withania somnifera and Tinospora cordifolia in rats using plethysmograph has been initiated.Objectives:1) To study the anti-inflammatory effect of Withania somnifera and Tinospora cordifolia in male albino wistar rats. 2) To compare anti inflammatory effect of Withania somnifera (ashwagandha) with Tinospora cordifolia (guduchi) in male albino wistar rats by using plethysmographMethodology: A Randomized controlled trial was conducted in the Dept. of Pharmacology, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation (Dr.PSIMS), Chinoutapalli, Krishna District, Andhra Pradesh with the institutional ethical committee clearance. All male albino wistar rats weighing between 250-300gm were selected for the study andrats were randomly divided into 3 groups (Control, Test-1 & Test-2).0.2 ml of normal saline was administered to Control group rats, Withania somnifera in a dose of 25.69mg/kg BW was administered to test-1 group rats, Tinospora cardifolia in a dose of 25.69 mg/kg BW was administered to test-2 group rats, as single oral dose half an hour before injecting 0.1ml of 1% carrageenan to the sub-plantar region of hind paw and the paw edema of each rat was measured at 3hours.Conclusion: The results showed that found that the Withania somnifera has more effective anti-inflammatory activity than tinospora cordifolia. However the above preclinical experiments only give us an idea about the anti-inflammatory activity of Withania somnifera and Tinosopra cordifolia but large scale clinical trials are necessary for final assessment.