Abstract

The pancreas derives its name from the Greek ‘pan means all’ and ‘creas means flesh’. It is an organ containing two distinct population of cells.Endocrine cells are Islets of Langerhans that secrete hormones insulin and glucagon which together regulate blood glucose levels and also secrets somatostatin[1] . The exocrine cells pancreatic acini secrete enzymes amylase, salts and alpha fetoproteina major serum protein during development. Pancreatic alpha fetoproteinhas found to change the expression level during development and has been suggested to influence the pancreatic development.[2] The purpose of this paper is to focus on histogenesis of Pancreas in fresh human aborted foetuseswithout gross abnormalityfrom 12 to 40 weeks of gestational age. The foetuses were preserved in formalin and they were of both the sexes. And they were obtained from the department of obstetrics and gynaecology, KIMS Narkatpally, Nalgonda (Dt), Telangana, (INDIA). Five stages of development of pancreatic acini were screened by haematoxylin and eosin staining and were observed under light microscope.The developmental study of pancreatic acini were discussed with the findings from the available literature. The gaps of knowledge is necessary to understand the histogenesis of pancreas at various gestational ages which helps in planning new therapeutic strategies in reducing mortality and curing either or both diseases, pancreatic cancer and diabetes mellitus . Majority of studies focus on foetal pancreatic islets, but few studies were focus on the foetal pancreatic acini. Literature of development of human foetal pancreatic acini were few in number so that the present study was conducted to know the normal development of exocrine part of human foetal pancreas and its clinical correlation.