Abstract

Introduction: Prevalence of metabolic syndrome (MS) range from 33 to 40% in India and obesity derived insulin resistance is considered to be the main culprit. Beneficial effect of vitamin D on insulin resistance has been shown previously. We aim to show the prevalence of vitamin D deficiency in patients who are diagnosed with insulin resistance and the effect vitamin D supplementation would have on various components of MS. Methodology: All patients who presented to LokmanyaTilak Municipal Medical College and General Hospital, Mumbai from January 1, 2013 to December 31, 2013 were considered for the study. Patients who were diagnosed as MS according to the International Diabetes Federation criteria were consented and enrolled for the study. A set of biometric and biochemical investigations were done and were repeated after 10 weeks of vitamin D supplementation (60,000 IU sachet/week). Chi-square and t-test were applied to look for test of significance. Results: 51 patients were included in the study; 65% males, 51.7 years mean age, 80% patients vitamin D deficient. We observed statistically significant decrease in waist circumference, body mass index, systolic and diastolic blood pressures, serum triglyceride, fasting blood sugar, fasting insulin levels, insulin resistance and hemoglobin A1c. Additionally, patients with vitamin D deficiency (

<20ng/dL) showed the greatest response;fasting blood sugar decreased significantly (p=0.0072). Conclusion: We support the practice of obtaining plasma vitamin D levels in patients at risk of or diagnosed with MS. Vitamin D supplementation resulted in statistically significant improvement in various biometric and biochemical markers of MS.>