Abstract
Stroke is a fundamental cause of many cardiac disorders, and formation of Blood clots or thrombi (embolus) in the arterial circulation can lead to unstable angina, myocardial infarction, or ischemic stroke. Anticoagulant therapy is extensively used with establish benefit to prevent ischemic stroke and thromboembolic events in patients with atrial fibrillation (AF). Atrial fibrillation causes a major trouble on heart patients and CVS. Risk of stroke is increase in case of AF.The main goals of Anticoagulant therapy are to improve symptoms, reduce morbidity, mortality and chances of stroke. The results of many studies emphasize the importance of effective oral anticoagulant therapy in patients with moderate-to-high risk for stroke and superiority of dabigatran, an oral direct thrombin inhibitor, over warfarin in the prevention of stroke. Novel anticoagulants in developments may overcome some of limitations of vitamin k antagonist and address their underuse and safety concerns. : Atrial Fibrillation, Cardio vascular system.