Abstract
Diabetes mellitus (DM) is a metabolism disease marked by the hyperglycemia that occurs because of insulin disorders. The failures of pancreatic beta cells and insulin resistance in peripheral tissues are the main reasons for DM disorder. A Paitan Leaf (Thitonia diversifolia) has flavonoid compounds that can lower the production of glucose and regenerate damaged pancreatic islets of Langerhans cells. The purpose of this study was to investigate the impacts of giving the extracts of Paitan leaves (T. diversifolia) orally to repair the histopathology description of pancreas in diabetic mice (Mus musculus). A total of 25 samples divided into 5 groups (control negative, control positive, treatment 1, treatment 2, and treatment 3). Before giving the treatment, all samples were checked for their glucose blood rate. The Pancreas of diabetic mice were then observed by using a microscope with 400x magnification. Histological parameters assessed were degrees of damaged pancreatic islets of Langerhans cells to figure out damage structure and infiltration cell inflammation. The successful parameter of induction was the increase of the rate of blood glucose. The result of this study using the analysis of the Chi-Square test showed the significant difference by giving the extract of Paitan leaves with description histopathology value P = 0.012 (p <0.05). Giving the extract of Paitan leaves (T. diversifolia) reduces damages of pancreatic islets of Langerhans cells