Abstract

Biofilm-forming bacterium represents a major medical problem because of the decreased susceptibility of bacteria, within the biofilm, to host defenses and antibiotic treatments. In particular, Proteus mirabilis and Candida albicans biofilm play an important role in various wound and urinary tract infections. The aim of this study was to evaluate the ability of different culture supernatants derived from Lactobacillus spp. to contrast P. mirabilis and C. albicans biofilm formation. We demonstrated that supernatants derived from L. plantarum markedly contrast P. mirabilis and C. albicans biofilm formation. The supernatants did not lost their activity if collected at 24, 48 or 72 hours. In addition, L. plantarum supernatant reduced the vitality of P. mirabilis and C. albicans sessile cells. The results here presented might suggest the ability of molecules released by L. plantarum to act both on preformed biofilm and on microrganisms released by dispersed biofilm, avoiding distant colonization.