Abstract

Objective(s) : To study and compare the effectiveness of chorioamniotic Membrane sealing drug (Amnioseal) in premature rupture of membrane (PROM) with conventional treatment in terms of prolongation in gestational age and perinatal outcome. Method(s): This randomized control trial conducted in dept. of obs and gynae, SMS Medical College, Jaipur. 210 antenatal patients (pts) with prelabour PROM recruited for the study. They divided into 2 groups of gestational age 24-30 weeks (Group A) and 31-36 weeks (Group B). These groups further subdivided into A1, A2 and B1, B2 respectively. Out of them A1, B1 were cases and A2, B2 were controls. All the patients put on rest, antibiotics, prophylactic corticosteroids and tocolytics (conventional treatment). Amnioseal added to conventional treatment in cases of A1, B1. Results observed. Result(s) : In 24-30 weeks i.e. group A ,Mean prolongation of gestational age was 6.00 ± 3.87 wks (cases A1) versus 5.56 ± 3.46 wks (controls A2) while in 31-36 weeks i.e. group B, prolongation was 4.00 ± 2.42 weeks (cases B1) versus 3.50 ± 2.84 weeks (controls B2)(significant). In-group A mean birth weight was 1.80 ± 0.76 kg (in A1) versus 1.66 ± 0.72 kg (in A2), while 2.43 ± 0.44 kg (in B1) versus 2.20 ± 0.52 kg (in B2) (significant). Perinatal outcome was better in cases (A1 & B1). Conclusion(s): Membrane sealing drug (Amnioseal) has a definite role in PROM as it helps in prolongation of gestational age and improves fetal outcome

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