Abstract
Due to high level of blood sugar, some glucose molecules are attached to the normal hemoglobin which is known as glycated hemoglobin (HbA1c). HbA1c indicates the average blood glucose levels over the past 6 to 8 weeks. Therefore, it has been recommended as a screening tool for the detection and monitoring of diabetes mellitus. HbA1c at high levels are associated with various metabolic disorder and other disease. In the present review, we summarized risk factors associated with increased level of HbA1c and its clinical significance.