Abstract

Background: Generally defined, anemia is present when the hemoglobin concentration is below a normal value based on the reference population. The mean normal value of hemoglobin is dependent on age, gender, race, and altitude. According to WHO criteria, the lower limit of normal in adults is 13 g/dL in men and 12 g/dL in women. Anaemia is believed to increase the risk of surgery, and it is common practice for non-urgent surgery to be postponed if a patient is anaemic. The level of circulating haemoglobin below which such an effect exists is, however, unknown. Nor is it known whether the risk is real. The justification for considering anaemia as a risk is based on the theoretical concept of oxygen flux (Freeman and Nunn, 1963). This study is aimed to evaluate the efficacy of the combination therapy of intravenous iron sucrose and subcutaneous human recombinant erythropoietin alpha therapy in reducing the need for blood transfusion and maintenance of hemoglobin level in perioperative management of patients undergoing elective surgery. Methods: A hospital based Prospective Comparative Study was undertaken among pre-operative patients. It is a prospective randomized control trial. A total number of 100 patients (50 in each group) will be enrolled. Group A will be study group and Group B will be control group. Patient will be screened prior to enrollment and eligibility will be assessed by specific inclusion and exclusion criteria.