Abstract
The antihyperlipidemic and hepatoprotective effect of Brassica oleracae var. capitata L. were investigated on triton-induced hyperlipidemic rats. Standard procedures were used to determine the phytochemical constituents. Hyperlipidemia was induced in albino rats by administration of a single dose of freshly prepared Triton X-100 (100mg/kg, i.p) after an overnight fast of 18 hours. The result of the phytochemical analysis showed appreciable level of Alkaloids (95.53±1.01mg/100g), Phenols (166.83±2.21mg/100g), Flavonoids (38.02±1.60mg/100g), Saponins (33.80±0.48mg/100g), and low level of Tannins (2.84±0.60mg/100g). The administration of Triton X-100 caused significant (p
<0.05) increase in the level of serum total cholesterol (TC), Triglycerides (TG), Low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VDL-cL) respectively and significantly (p><0.05) decrease High density lipoprotein cholesterol (HDL-c) level compared with normal control group. However, treatment of hyperlipidemic rats with Methanolic extract and Petroleum ether extract at 100mg/kg, 300mg/kg and 500mg/kg body weight of animal caused significant (p><0.05) decrease in the levels of serum TC, TG, LDL-c, VLDL-c respectively and significant (p><0.05) increase in HDL-c level at a dose dependent manner compared with the hyperlipidemic control. Methanolic extract and Petroleum ether extract at 500mg/kg body weight were observed to elicit the highest hypolipidemic effect on serum lipid profile by decreasing the levels of TC by 41.3% and 40.9%, TG by 56.7% and 48.7%, LDL-c by 44% and 48.5%, VLDL-c by 56.7% and 48.7% respectively, and increases the level of HDL-c by 115% and 94.5%. The extracts (in a dose dependent manner) also exhibited correction of altered biochemical parameters-SGOT, SGPT and Alkaline phosphatase. Treatment with Methanolic and Petroleum ether extracts at 500mg/kg body weight exhibited quite competitive potential and generally elicited comparable effects when compared with the reference drug Atorvastatin (10mg/kg body weight) which indicates that Brassica oleracae var. Capitata L. extracts could be explored as alternative therapeutic agent in the treatment of hyperlipidemia with favourable hepatoprotective activity. >
