Abstract

The present investigation was carried out to evaluate the effect of plant formulation(Ziziphus spinachristi leaves , Alhagi maurorum roots, Zea mays silk, Hordeum vulgare grains and Pimpinella anisum seeds) extract on kidney of Sodium oxalate induced urolithiasis in rats. The aqueous extract of plant formulatiom /standard drug cystone were administrated simultaneously at a dose of 100, 200 or 400 mg/kg body weight/day, along with sodium oxalate (70 mg/kg body weight/day) w/v) for 30 days. Significant changes were observed in body weight and kidney weight of sodium oxalate treated rats. Histopathological results showed disrupted renal parenchyma showing loss of structural arrangement of renal tubules, early degenerative changes in glomeruli and focal calcification in glomerulo-tubular structures were observed in the renal tissue of urolithiatic rats .Cystic dilation of renal tubules with completing distraction of other due to necrosis with thickening of Bowman's capsules . Hydropic degeneration of proximal and distal renal tubules leading narrowing it's Lumenic in sodium oxalate treated animals. Administration of plant formula extract or cystone along with sodium oxalate showed significant protective effect in body weight , kidney weight, with few stray areas of calcification in glomeruli and normal tubular structures, increased cellularity between tubules is clearly visible . Moreover, plant formula extract shows higher renoprotective than cystone .In conclusion, Aqueous extract of the formulation of these plants has proved to be an effective drug in prevention of nephrolithiasis