Abstract

In patients with diabetes mellitus (DM), chronic infections are frequent and severe due to the impairment
of their immune status. However, data on the prevalence of Helicobacter pylori (H. pylori) infection in
DM type II (DMT2) are scanty and contradictory. Aim of this study was to evaluate the prevalence of H.
pylori infection in DMT2 patients in Northern region of India (Rajasthan state, more specifically in and
around the rural area of Pilani) and also to find if there exists any significant correlation between H.
pylori infection and DMT2. The study was carried out in rural Rajasthan. A case control study of 72
patients (33 diabetics and 39 non-diabetic subjects) was designed for the period of six month. The study
design was based on pre-decided inclusion and exclusion criteria. Blood samples were collected from
controls and DMT2 patients after obtaining informed consent. Anti - H. pylori - IgG Microplate ELISA
test was performed for presence or absence of H. pylori. Differences between DMT2 patients and controls
were evaluated based on statistical analysis. Data was analyzed by using Chi-square test at 5 % level of
significance. The difference of H. pylori prevalence between diabetics (88%) and control (67%) was
significant (p<0.05) showing strong correlation between the association of H. pylori and DMT2.
Key Words: Diabetes Type II, H. pylori, Ulcer, Case Control Study